Tenamfetamine

Base Information

• Chemical Name: Tenamfetamine
• CAS No.: 51497-09-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 51497-09-7.mol

Synonyms:Tenamfetamine;1-(1,3-BENZODIOXOL-5-YL)PROPAN-2-AMINE;

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Chemical Property of Tenamfetamine

Chemical Property:

• Vapor Pressure: 0.0035mmHg at 25°C
• Boiling Point: 281.7°C at 760 mmHg
• Flash Point: 134.9°C
• PSA: 44.48000
• LogP: 2.00530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tenamfetamine

There total 5 articles about Tenamfetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → (-)-Tenamfetamine (4764-17-4,51497-09-7,61614-60-6,65620-66-8)

Guidance literature:

With pyridoxal 5'-phosphate; amine transaminase TA-P₂-B₀₁; isopropylamine; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/adsc.201900179

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → (+)-Tenamfetamine (65620-66-8) + (-)-Tenamfetamine (4764-17-4,51497-09-7,61614-60-6,65620-66-8)

Guidance literature:

With pyridoxal 5'-phosphate; amine transaminase ATA-412; isopropylamine; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/adsc.201900179

Reference yield:

1-allyl-3,4-methylenedioxybenzene (94-59-7) → (-)-Tenamfetamine (4764-17-4,51497-09-7,61614-60-6,65620-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium 2,2,2-trifluoroacetate; iron(III) chloride; palladium(II) trifluoroacetate / acetonitrile; water / 60 °C / Inert atmosphere; Darkness

2: pyridoxal 5'-phosphate; isopropylamine; amine transaminase TA-P₂-B₀₁ / aq. phosphate buffer / 24 h / 30 °C / pH 7.5 / Enzymatic reaction

With iron(III) chloride; palladium(II) trifluoroacetate; pyridoxal 5'-phosphate; amine transaminase TA-P₂-B₀₁; sodium 2,2,2-trifluoroacetate; isopropylamine; In aq. phosphate buffer; water; acetonitrile; 1: |Wacker-Tsuji Olefin Oxidation;

DOI:10.1002/adsc.201900179

upstream raw materials:

(-)-3,4-Methylenedioxymethamphetamine

1-(1,3-benzodioxol-5-yl)-2-propanone

1-allyl-3,4-methylenedioxybenzene

Downstream raw materials:

(-)-3,4-Methylenedioxymethamphetamine