Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-

Base Information

Chemical Name:Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-
CAS No.:112886-49-4
Molecular Formula:C22H25 Cl F3 N3 O3
Molecular Weight:471.9004
Hs Code.:
DSSTox Substance ID:DTXSID60920932
Nikkaji Number:J374.033A
ChEMBL ID:CHEMBL351553

Synonyms:BRN 4278534;112886-49-4;Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-;C22H25ClF3N3O3;CHEMBL351553;DTXSID60920932;C22-H25-Cl-F3-N3-O3;LS-25431;4-Amino-5-chloro-2-ethoxy-N-[[4-(3-trifluoromethylbenzyl)-2-morpholinyl]methyl]benzamide;4-Amino-5-chloro-2-ethoxy-N-[(4-{[3-(trifluoromethyl)phenyl]methyl}morpholin-2-yl)methyl]benzene-1-carboximidic acid

Suppliers and Price of Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-

Chemical Property:

Vapor Pressure:7.15E-12mmHg at 25°C
Boiling Point:543.5°Cat760mmHg
Flash Point:282.5°C
Density:1.307g/cm³
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:471.1536538
Heavy Atom Count:32
Complexity:613

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC(=CC=C3)C(F)(F)F)Cl)N

Technology Process of Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)-

There total 3 articles about Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((3-(trifluoromethyl)phenyl)methyl)-2-morpholinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112913-96-9
2-(N-acetylaminomethyl)-4-benzylmorpholine

: 112886-49-4
4-Amino-5-chloro-2-ethoxy-N-[4-(3-trifluoromethyl-benzyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, AcOH / 10percent Pd/C / ethanol / 60 °C

2: 98 percent / K₂CO₃, KI / butan-2-one / 17 h / Heating

3: 94 percent / 10percent HCl / 4 h / Heating

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; palladium on activated charcoal; In ethanol; dichloromethane; butanone;
DOI:10.1021/jm00106a023

Reference yield:

: 59-06-3
methyl 4-acetamido-2-ethoxybenzoate

: 112886-49-4
4-Amino-5-chloro-2-ethoxy-N-[4-(3-trifluoromethyl-benzyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / N-chlorosuccinimide (NCS) / dimethylformamide / 2 h / 70 °C

2: 99 percent / NaOH, H₂O / ethanol / 5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; N-chloro-succinimide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a023

Reference yield:

: 108282-38-8
4-amino-5-chloro-2-ethoxybenzoic acid

: 131322-24-2
2-(aminomethyl)-4-<3-(trifluoromethyl)benzyl>morpholine

: 112886-49-4
4-Amino-5-chloro-2-ethoxy-N-[4-(3-trifluoromethyl-benzyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 4h; Yield given; Ambient temperature;
DOI:10.1021/jm00106a023