7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Base Information

Chemical Name:7-ethyl-10-methoxy-20-deoxyaminocamptothecin
CAS No.:126266-02-2
Molecular Formula:C₂₃H₂₃N₃O₄
Molecular Weight:405.453
Hs Code.:
Mol file:126266-02-2.mol

Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-amino-4,11-diethyl-9-methoxy-, (?à)-

Suppliers and Price of 7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Chemical Property:

Vapor Pressure:2.52E-23mmHg at 25°C
Boiling Point:765.2°Cat760mmHg
Flash Point:416.6°C
PSA：96.44000
Density:1.39g/cm³
LogP:3.31730

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-ethyl-10-methoxy-20-deoxyaminocamptothecin

There total 7 articles about 7-ethyl-10-methoxy-20-deoxyaminocamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 60997-56-0
2'-amino-5'-methoxypropiophenone

: 141998-36-9
4-amino-4-ethyl-7,8-dihydro-1H-pyrano<3,4-f>indolizine-3,6,10(4H)-trione*CF3CO2H

: 126266-02-2
(+/-)-7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 4h; Heating;
DOI:10.1248/cpb.40.683

Reference yield: 45.0%

: 60997-56-0
2'-amino-5'-methoxypropiophenone

: 126266-09-9
4-Amino-4-ethyl-1,4,7,8-tetrahydro-pyrano[3,4-f]indolizine-3,6,10-trione

: 126266-02-2
(+/-)-7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Guidance literature:: toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1248/cpb.37.2253

Reference yield:

: 102978-41-6
4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione

: 126266-02-2
(+/-)-7-ethyl-10-methoxy-20-deoxyaminocamptothecin

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / pyridine

2: NaN₃ / dimethylformamide / 60 °C

3: 53 percent / H₂ / 10 percent Pd-C

4: 80 percent aq. TFA

5: 45 percent / p-TsOH / toluene / Heating

With pyridine; sodium azide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.37.2253