Dapiramicin B

Base Information

Chemical Name:Dapiramicin B
CAS No.:90044-18-1
Molecular Formula:C₂₁H₂₉N₅O₁₁
Molecular Weight:527.488
Hs Code.:
DSSTox Substance ID:DTXSID60238004
Nikkaji Number:J111.118C
Wikidata:Q83120267
Metabolomics Workbench ID:144131
Mol file:90044-18-1.mol

Synonyms:dapiramicin B

Suppliers and Price of Dapiramicin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Dapiramicin B

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:914°Cat760mmHg
Flash Point:506.6°C
PSA：244.92000
Density:1.66g/cm³
LogP:-3.39872
XLogP3:-3.3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:8
Exact Mass:527.18635676
Heavy Atom Count:37
Complexity:806

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1C(OC(C(C1O)O)OC2C(OC(C(C2O)O)NC3=NC4=C(C(=CN4)C#N)C(=N3)OC)CO)CO
Isomeric SMILES:CO[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)NC3=NC4=C(C(=CN4)C#N)C(=N3)OC)CO)CO

Technology Process of Dapiramicin B

There total 9 articles about Dapiramicin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 908845-63-6
C₇₅H₉₁N₅O₁₈Si

: 90044-18-1
dapiramicin B

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2006.06.001

Reference yield:

: 908845-55-6
2-bromo-4-methoxy-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

: 90044-18-1
dapiramicin B

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaO(t-Bu) / Pd₂(dba)3; (S)-BINAP / toluene / 6 h / 80 °C

2: 92 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.5 h / 0 °C

With boron trifluoride diethyl etherate; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2006.06.001

Reference yield:

: 908845-60-3
2-amino-4-oxo-7-(2-trimethylsilanyl-ethoxymethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

: 90044-18-1
dapiramicin B

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / silicic acid; NaHCO₃ / methanol; diethyl ether / sonication

2: 72 percent / SBr₃; t-BuONO / various solvent(s) / 0 °C

3: 55 percent / NaO(t-Bu) / Pd₂(dba)3; (S)-BINAP / toluene / 6 h / 80 °C

4: 92 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.5 h / 0 °C

With tert.-butylnitrite; boron trifluoride diethyl etherate; sodium hydrogencarbonate; silicic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2006.06.001