2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE

Base Information

• Chemical Name: 2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE
• CAS No.: 1629-07-8
• Molecular Formula: C13H8FNS
• Molecular Weight: 229.278
• Hs Code.: 2934999090
• Mol file: 1629-07-8.mol

Synonyms:Benzothiazole,2-(m-fluorophenyl)- (7CI,8CI);NSC 51876;

Chemical Property of 2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE

Chemical Property:

• Vapor Pressure: 4.34E-05mmHg at 25°C
• Melting Point: 71-73 °C
• Refractive Index: 1.663
• Boiling Point: 361.3 °C at 760 mmHg
• PKA: 0.38±0.10(Predicted)
• Flash Point: 172.3 °C
• PSA: 41.13000
• Density: 1.304 g/cm³
• LogP: 4.10240

Purity/Quality:

99% ^*data from raw suppliers

2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE

There total 24 articles about 2-(3-FLUOROPHENYL)-1,3-BENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-iodophenylamine (615-43-0) + 3-Fluorobenzaldehyde (456-48-4) → 2-(3-fluorophenyl)benzo[d]thiazole (1629-07-8)

Guidance literature:

With magnesium sulfate; copper(l) chloride; In dimethyl sulfoxide; at 110 ℃; for 6h;

DOI:10.1002/ejoc.201101773

Reference yield: 95.0%

2-amino-benzenethiol (137-07-5) + 3-Fluorobenzaldehyde (456-48-4) → 2-(3-fluorophenyl)benzo[d]thiazole (1629-07-8)

Guidance literature:

With laccase; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In aq. phosphate buffer; at 20 ℃; for 1h; pH=5; Green chemistry; Enzymatic reaction;

DOI:10.1039/c9ra10303a

Reference yield: 95.0%

N-(2-bromophenyl)-3-fluorobenzothioamide → 2-(3-fluorophenyl)benzo[d]thiazole (1629-07-8)

Guidance literature:

With sodium phosphate; In dimethyl sulfoxide; at 20 ℃; for 10h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.1c00235

upstream raw materials:

2-amino-benzenethiol

3-fluorobenzoyl chloride

m-Fluorobenzonitrile

2-bromo-1,3-benzothiazole

Downstream raw materials:

2-(benzo[d]thiazol-2-yl)-4-fluoro-phenol