Technology Process of 1-(Hydroxymethyl)-5,7-dimethyl-4-(phenylmethyl)-2,3-dithia-5,7-diazabicyclo(2.2.2)octane-6,8-dione
There total 8 articles about 1-(Hydroxymethyl)-5,7-dimethyl-4-(phenylmethyl)-2,3-dithia-5,7-diazabicyclo(2.2.2)octane-6,8-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(4-methoxyphenyl)-6,8-dimethyl-1-hydroxymethyl-5-(phenylmethyl)-2,4-dithia-6,8-diazabicyclo[3.2.2]nonaiie-7,9-dione;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
With
perchloric acid; dimethylsulfide;
In
methanol; dichloromethane;
at 0 - 20 ℃;
for 9h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: bromine / 1,2-dichloro-benzene / 150 °C
2.1: triethylamine / chloroform; acetone / 4 h / 4 °C
3.1: hydrogenchloride / diethyl ether; methanol / 2 h / Reflux
4.1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.03 h / -78 °C
5.2: -78 - 20 °C
6.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C
7.1: boron trichloride / dichloromethane / 0.17 h / 0 °C
8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C
8.2: 9 h / 0 - 20 °C
With
hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; bromine; boron trichloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; 1,2-dichloro-benzene; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C
2.1: boron trichloride / dichloromethane / 0.17 h / 0 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C
3.2: 9 h / 0 - 20 °C
With
n-butyllithium; boron trichloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane;
