Chemical Property of Fortunellin
Chemical Property:
- Vapor Pressure:6.89E-34mmHg at 25°C
- Melting Point:193-198oC
- Boiling Point:888.7°Cat760mmHg
- PKA:6.10±0.40(Predicted)
- Flash Point:293.4°C
- PSA：217.97000
- Density:1.62g/cm3
- LogP:-0.79530
- XLogP3:0.1
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:14
- Rotatable Bond Count:7
- Exact Mass:592.17920569
- Heavy Atom Count:42
- Complexity:955
- Purity/Quality:
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Analysis control,HPLC≥95% *data from raw suppliers
Acacetin-7-neohesperidoside *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)OC)O)CO)O)O)O)O)O
- Isomeric SMILES:C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)OC)O)CO)O)O)O)O)O
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Description
Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.
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Biological Functions
Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.
