17-Ethinyl-dihydrotestosterone

Base Information

Chemical Name:17-Ethinyl-dihydrotestosterone
CAS No.:13611-97-7
Molecular Formula:C₂₁H₃₀O₂
Molecular Weight:314.468
Hs Code.:
ChEMBL ID:CHEMBL260202
DSSTox Substance ID:DTXSID80929265
Nikkaji Number:J379.011H
Pharos Ligand ID:YLZCQ71V6JUP
Mol file:13611-97-7.mol

Synonyms:17-ethinyl-dihydrotestosterone;CHEMBL260202;SCHEMBL10605540;DTXSID80929265;BDBM50423536;17alpha-Ethynyl-17-hydroxy-5alpha-androstan-3-one

Suppliers and Price of 17-Ethinyl-dihydrotestosterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 17-Ethinyl-dihydrotestosterone

Chemical Property:

Vapor Pressure:4.01E-09mmHg at 25°C
Boiling Point:428.1°C at 760 mmHg
Flash Point:182.6°C
Density:1.11g/cm³
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:314.224580195
Heavy Atom Count:23
Complexity:586

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4(C#C)O)C
Isomeric SMILES:C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C

Technology Process of 17-Ethinyl-dihydrotestosterone

There total 6 articles about 17-Ethinyl-dihydrotestosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 13611-96-6
(3S,5S,8R,9S,10S,13S,14S,17R)-17-Ethynyl-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol

: 13611-97-7
17α-ethynyldihydrotestosterone

Guidance literature:: With pyridine-SO₃ complex; 4 A molecular sieve; triethylamine; In dichloromethane; dimethyl sulfoxide; for 16h;
DOI:10.1039/b610499a

Reference yield:

: 481-29-8
Epiandrosterone

: 13611-97-7
17α-ethynyldihydrotestosterone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) CH₃Li / 1.) ether, from 0 deg C to RT, 1 h, 2.) THF, from 0 deg C to RT, 4 h

2: aq. KOH / methanol / 0.5 h / 65 - 70 °C

3: 57 percent / 4A molecular sieves, N-methylmorpholine N-oxide, tetra-n-propylammonium perruthenate / tetrahydrofuran / 14 h / Ambient temperature

With potassium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; methyllithium; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00107a021

Reference yield:

: (3S,5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-trimethylsilanylethynyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol

: 13611-97-7
17α-ethynyldihydrotestosterone

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / methanol / 0.5 h / 65 - 70 °C

2: 57 percent / 4A molecular sieves, N-methylmorpholine N-oxide, tetra-n-propylammonium perruthenate / tetrahydrofuran / 14 h / Ambient temperature

With potassium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00107a021