5-Methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 5-Methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine
• CAS No.: 16942-66-8
• Molecular Formula: C11H12 N2 S
• Molecular Weight: 204.296
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID80351522
• Wikidata: Q82127994
• ChEMBL ID: CHEMBL369449
• Mol file: 16942-66-8.mol

Synonyms:16942-66-8;5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine;5-Methyl-4-(p-tolyl)thiazol-2-amine;5-Methyl-4-p-tolylthiazol-2-amine;5-Methyl-4-p-tolyl-thiazol-2-ylamine;5-methyl-4-(4-methylphenyl)-2-thiazolamine;Oprea1_454660;Oprea1_752913;MLS000760343;CHEMBL369449;SCHEMBL2303869;DTXSID80351522;LARKPJHOVACKEM-UHFFFAOYSA-N;HMS2765B16;BBL016452;MFCD01627875;STK422126;AKOS000116901;CCG-105318;AS-43524;SMR000373061;BB 0254257;CS-0153073;FT-0678520;EN300-08659;A882093;SR-01000418191;SR-01000418191-1;Z48847632;5-METHYL-4-(4-METHYLPHENYL)-1,3-THIAZOL-2-YLAMINE

Chemical Property of 5-Methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 2.42E-05mmHg at 25°C
• Boiling Point: 359.2°Cat760mmHg
• Flash Point: 171°C
• PSA: 67.15000
• Density: 1.185g/cm³
• LogP: 3.59030
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 204.07211956
• Heavy Atom Count: 14
• Complexity: 190

Purity/Quality:

97% ^*data from raw suppliers

5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=C(SC(=N2)N)C

Technology Process of 5-Methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine

There total 4 articles about 5-Methyl-4-(4-methylphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-4'-methylpropiophenone (92821-88-0,1451-82-7) + thiourea (17356-08-0) → 2-amino-4-(4’-methylphenyl)-5-methyl-1,3-thiazole (16942-66-8)

Guidance literature:

In ethanol; for 1h; Reflux;

Reference yield: 79.0%

4'-methylpropiophenone (5337-93-9) + thiourea (17356-08-0) → 2-amino-4-(4’-methylphenyl)-5-methyl-1,3-thiazole (16942-66-8)

Guidance literature:

With iodine; for 8h; Heating;

DOI:10.14233/ajchem.2017.20925

Reference yield: 22.0%

thiourea (17356-08-0) + para-methylacetophenone (122-00-9) → 2-amino-4-(4’-methylphenyl)-5-methyl-1,3-thiazole (16942-66-8)

Guidance literature:

para-methylacetophenone; With bromine; In acetonitrile; at 25 - 100 ℃; for 2h;

thiourea; In acetonitrile; at 25 - 100 ℃; for 2h;

DOI:10.1021/jm501402x

upstream raw materials:

4'-methylpropiophenone

thiourea

2-bromo-4'-methylpropiophenone

para-methylacetophenone

Downstream raw materials:

N,N-phthaloyl-glycine 5-methyl-4-p-tolyl-thiazol-2-ylamide

(5-methyl-4-p-tolyl-thiazol-2-yl)-(4-nitro-benzylidene)-amine

2-(4-chloro-phenoxy)-N-(5-methyl-4-p-tolyl-thiazol-2-yl)-acetamide

(5-methyl-4-p-tolyl-thiazol-2-yl)-(2-nitro-benzylidene)-amine