3-SULFAMOYL-BENZOIC ACID

Base Information

• Chemical Name: 3-SULFAMOYL-BENZOIC ACID
• CAS No.: 636-76-0
• Molecular Formula: C7H7NO4S
• Molecular Weight: 201.203
• Hs Code.: 29350090
• Mol file: 636-76-0.mol

Synonyms:Benzoicacid, m-sulfamoyl- (6CI,7CI,8CI);Benzoic acid, m-sulfamyl- (4CI);3-Aminosulfonylbenzoic acid;3-Carboxybenzenesulfonamide;3-Sulfamoylbenzoicacid;NSC 22977;NSC 85501;m-Sulfamidobenzoic acid;

Chemical Property of 3-SULFAMOYL-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 7.15E-10mmHg at 25°C
• Melting Point: 251-252℃
• Refractive Index: 1.611
• Boiling Point: 476.1 °C at 760 mmHg
• PKA: pK1:3.54 (25°C)
• Flash Point: 241.7 °C
• PSA: 105.84000
• Density: 1.536 g/cm³
• LogP: 1.81330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Sulfamoyl-benzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-24/25-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-SULFAMOYL-BENZOIC ACID

There total 7 articles about 3-SULFAMOYL-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-Carboxybenzenesulfonyl chloride (4025-64-3) → 3-sulfamoylbenzoic acid (636-76-0)

Guidance literature:

3-Carboxybenzenesulfonyl chloride; With ammonia; In water; at 0 - 20 ℃; for 15h;

With hydrogenchloride; In water;

Reference yield:

benzoic acid (65-85-0,8013-63-6) → 3-sulfamoylbenzoic acid (636-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 125 °C

2: water; ammonia

With chlorosulfonic acid; ammonia; water;

Reference yield:

3-methylbenzenesulfonamide (1899-94-1) → 3-sulfamoylbenzoic acid (636-76-0)

Guidance literature:

With potassium permanganate;

DOI:10.1109/65.844495

upstream raw materials:

3-methylbenzenesulfonamide

3-Carboxybenzenesulfonyl chloride

3-cyanobenzenesulfonamide

3-methylphenylsulfonyl chloride

Downstream raw materials:

ethyl 3-sulfamoyl benzoate

3-nitro-5-sulfo-benzoic acid

3-cyanobenzene sulfonyl chloride

3-sulfonamidobenzoyl chloride

Refernces

• 1、 Swain, Baijayantimala,Abhay,Singh, Priti,Angeli, Andrea,Aashritha, Kamtam,Nagesh, Narayana,Supuran, Claudiu T.,Arifuddin, Mohammed. "3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation". . . Retrieved 2021/02/27.
• 2、 -. "INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE". Paragraph 00495-00496. . Retrieved 2020/06/10.