Chemical Property of 1-[(5-Methoxy-3-indolylidene)methylamino]-2-pentylguanidine
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:2.15E-18mmHg at 25°C
- Melting Point:155°
- Boiling Point:470.556 °C at 760 mmHg
- PKA:15.81±0.30(Predicted)
- Flash Point:238.384 °C
- PSA：159.89000
- Density:1.189 g/cm3
- LogP:3.40790
- Storage Temp.:2-8°C
- XLogP3:2.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:8
- Exact Mass:301.19026037
- Heavy Atom Count:22
- Complexity:385
- Purity/Quality:
-
99% *data from raw suppliers
Tegaserod *data from reagent suppliers
Safty Information:
- Pictogram(s):
R20/21/22:;
- Hazard Codes:Xi
- Statements:
20/21/22-36/37/38
- Safety Statements:
36/37-36-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCN=C(N)NN=CC1=CNC2=C1C=C(C=C2)OC
-
Uses
Treatment of gastrointestinal motility disorders
(selective serotonin 5HT4antagonist).
-
Indications
Tegaserod (Zelnorm) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility.
-
Clinical Use
Tegaserod is being developed as a treatment for constipation-
predominant irritable bowel syndrome (IBS).
Within the first week, patients treated with tegaserod
had significant improvements in abdominal pain and discomfort,
constipation, and overall well-being. Efficacy
was maintained throughout the treatment period.
Tegaserod also demonstrated significant improvements
in the three bowel-related assessments (stool frequency,
stool consistency, and straining) within the first week,
and these improvements were sustained throughout the
treatment period. The most common adverse events reported
thus far are headache and diarrhea.
