1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Base Information

Chemical Name:1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
CAS No.:111218-74-7
Molecular Formula:C₁₇H₁₅Br₂N₅O₂*ClH
Molecular Weight:517.607
Hs Code.:
DSSTox Substance ID:DTXSID60149545
Mol file:111218-74-7.mol

Synonyms:111218-74-7;1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride;Piperazine, 1-(4-amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)-, monohydrochloride;[4-(4-amino-6,8-dibromoquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride;1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride;C17H15Br2N5O2.ClH;DTXSID60149545;MQRZVBWLTDCEQZ-UHFFFAOYSA-N;C17-H15-Br2-N5-O2.Cl-H;LS-110223

Suppliers and Price of 1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-AMINO-6,8-DIBROMO-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE HYDROCHLORIDE 95.00%
5MG
$ 500.25

Total 1 raw suppliers

Chemical Property of 1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Chemical Property:

Vapor Pressure:4.19E-18mmHg at 25°C
Boiling Point:675.5°Cat760mmHg
Flash Point:362.3°C
PSA：89.22000
Density:g/cm³
LogP:4.02740
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:516.93388
Heavy Atom Count:27
Complexity:519

Purity/Quality:

99% ^*data from raw suppliers

1-(4-AMINO-6,8-DIBROMO-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C2=NC3=C(C=C(C=C3Br)Br)C(=N2)N)C(=O)C4=CC=CO4.Cl

Technology Process of 1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

There total 4 articles about 1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.3%

: 111218-90-7
6,8-Dibromo-2-chloro-quinazolin-4-ylamine

: 40172-95-0
N-(furan-2-carbonyl)piperazine

: 111218-74-7
[4-(4-Amino-6,8-dibromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: In butan-1-ol; at 95 ℃; for 14h;
DOI:10.1007/BF00758756

Reference yield:

: 643-37-8
6,8-dibromoquinazoline-2,4-(1H,3H)-dione

: 111218-74-7
[4-(4-Amino-6,8-dibromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 84.9 percent / POCl₃, N,N-dimethylaniline / Heating

2: 88 percent / NH₃(g) / dimethylformamide / 0.67 h / 35 - 40 °C

3: 55.3 percent / butan-1-ol / 14 h / 95 °C

With ammonia; N,N-dimethyl-aniline; trichlorophosphate; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1007/BF00758756

Reference yield:

: 111218-87-2
6,8-dibromo-2,4-dichloroquinazoline

: 111218-74-7
[4-(4-Amino-6,8-dibromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NH₃(g) / dimethylformamide / 0.67 h / 35 - 40 °C

2: 55.3 percent / butan-1-ol / 14 h / 95 °C

With ammonia; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1007/BF00758756