venenatine

Base Information

• Chemical Name: venenatine
• CAS No.: 1055-75-0
• Molecular Formula: C₂₂H₂₈N₂O₄
• Molecular Weight: 384.475
• Mol file: 1055-75-0.mol

Synonyms:Venenatine(7CI); (-)-Venenatine; NSC 339139; Venenatin

Chemical Property of venenatine

Chemical Property:

• Vapor Pressure: 6.86E-14mmHg at 25°C
• Boiling Point: 571.3°Cat760mmHg
• Flash Point: 299.3°C
• PSA: 74.79000
• Density: 1.32g/cm³
• LogP: 2.59360

Purity/Quality:

98%,99%, ^*data from raw suppliers

VENENATINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: An Alstonia alkaloid, this base occurs in the bark of A. venenata R. Br. and has[α]24D - 76.07°. The hydriodide has m.p. 255-7°C (dec.); the picrate, m.p. 243° (dec.); the methiodide, m.p. 285-2900 C (dec.) and the O-acetate, m.p. 98-101°C (dec.). A methoxyl group, a non-phenolic hydroxyl group and a methoxycarbonyl group are present.

Technology Process of venenatine

There total 5 articles about venenatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + venenatic acid (4837-83-6) → venenatine (1055-75-0)

Guidance literature:

In methanol; diethyl ether; Ambient temperature;

DOI:10.1016/0031-9422(81)84049-6

Reference yield:

16-epialstovenine → venenatine (1055-75-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 52 percent / 2N KOH / methanol / 3 h / Heating

3: 20 percent / diethyl ether; methanol / Ambient temperature

With potassium hydroxide; In methanol; diethyl ether;

DOI:10.1016/0031-9422(81)84049-6

Reference yield:

16-epivenenatine (80735-17-7) → venenatine (1055-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / 2N KOH / methanol / 3 h / Heating

2: 20 percent / diethyl ether; methanol / Ambient temperature

With potassium hydroxide; In methanol; diethyl ether;

DOI:10.1016/0031-9422(81)84049-6

upstream raw materials:

diazomethane

venenatic acid

16-epivenenatine

Downstream raw materials:

alstovenine