1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE
• CAS No.: 33119-72-1
• Molecular Formula: C₆H₁₃NO*ClH
• Molecular Weight: 151.636
• Hs Code.: 2922399090
• Mol file: 33119-72-1.mol

Synonyms:a-Aminopinacolonehydrochloride;

Chemical Property of 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.304mmHg at 25°C
• Melting Point: 205 °C
• Boiling Point: 198.4 °C at 760 mmHg
• Flash Point: 73.8 °C
• PSA: 43.09000
• Density: 0.896g/cm3
• LogP: 2.06260
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Amino-3,3-dimethyl-2-butanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Amino-3,3-dimethyl-2-butanone Hydrochloride is used in the preparation of cyclin-dependant kinase 2 (CDK-2) inhibitors as selective antitumor agents.

Technology Process of 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE

There total 7 articles about 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-Bromopinacolon (5469-26-1) → C6H13NO*(x)ClH (33119-72-1)

Guidance literature:

1-Bromopinacolon; With acetonitrile; at 55 ℃; for 20h;

With hydrogenchloride; In isopropyl alcohol; for 48h;

Reference yield: 93.0%

1-Bromopinacolon (5469-26-1) → 1-amino-3,3-dimethylbutan-2-one hydrochloride (33119-72-1)

Guidance literature:

1-Bromopinacolon; With sodium azide; In acetone; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 18h;

DOI:10.1002/ejoc.201300541

Reference yield: 91.0%

1-azido-3,3-dimethyl-2-butanone (76779-98-1) → 1-amino-3,3-dimethylbutan-2-one hydrochloride (33119-72-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol;

upstream raw materials:

2,4-Bis(dimethylethyl)-2-methyl-2,5-dihydro-1H-imidazole

1-azido-3,3-dimethyl-2-butanone

1-phthalimido-3,3-dimethyl-butan-2-one

1-chloro-3,3-dimethyl-butan-2-one

Downstream raw materials:

2-bromo-N,N'-bis-(3,3-dimethyl-2-oxobutyl)-isophthalamide

tert-butyl 4-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl-carbamoyl)piperidine-1-carboxylate

SNS-032

α-N-2-(chloroacetylamino)pinacolone

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