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Technology Process of 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

Base Information
  • Chemical Name:1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
  • CAS No.:202463-68-1
  • Molecular Formula:C21H19Cl2IN4O2
  • Molecular Weight:557.21
  • Hs Code.:
  • European Community (EC) Number:633-840-7
  • UNII:SBP4A4DYH2
  • ChEMBL ID:CHEMBL476833
  • DSSTox Substance ID:DTXSID601122269
  • Nikkaji Number:J1.084.250F
  • Pharos Ligand ID:63TMLZ84RJCC
  • Wikidata:Q27074423
  • Mol file:202463-68-1.mol
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

Synonyms:AM 281;AM-281;AM281 cpd;N-(morpholin-4-yl)-5-(4-iodophenyl)-1-(2,4-dichlorphenyl)-4-methyl-1H-pyrazole-3-carboxamide

Suppliers and Price of 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Tocris
  • AM281 ≥99%(HPLC)
  • 50
  • $ 952.00
  • Tocris
  • AM281 ≥99%(HPLC)
  • 10
  • $ 227.00
  • Sigma-Aldrich
  • AM281 ≥98% (HPLC)
  • 10mg
  • $ 279.00
  • Sigma-Aldrich
  • AM281 ≥98% (HPLC)
  • 50mg
  • $ 971.00
  • DC Chemicals
  • AM281 >98%
  • 250 mg
  • $ 750.00
  • Chemenu
  • 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide 95+%
  • 100mg
  • $ 1630.00
  • Chemenu
  • 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide 95+%
  • 50mg
  • $ 1064.00
  • Chemenu
  • 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide 95+%
  • 10mg
  • $ 376.00
  • Cayman Chemical
  • AM281 ≥98%
  • 10mg
  • $ 125.00
  • Cayman Chemical
  • AM281 ≥98%
  • 5mg
  • $ 69.00
Total 22 raw suppliers
Chemical Property of 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
Chemical Property:
  • Appearance/Colour:White to off-white solid. 
  • Refractive Index:1.706 
  • PSA：59.39000 
  • Density:1.7 g/cm3 
  • LogP:5.06490 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: >6 mg/mL 
  • XLogP3:5.3
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:4
  • Exact Mass:555.99298
  • Heavy Atom Count:30
  • Complexity:589
Purity/Quality:

99%, *data from raw suppliers

AM281 ≥99%(HPLC) *data from reagent suppliers

Safty Information:
  • Pictogram(s): ToxicT 
  • Hazard Codes:T 
  • Statements: 25-36/37/38 
  • Safety Statements: 26-36/37/39-45 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
  • Description AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant . It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB1. It has also been used to study the membrane localization and cycling of CB1.
  • Uses AM 281 acts as a potential CB1 selective receptor cannabinoid antagonist.
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