2-Methylene-3(2H)-furanone

Base Information

Chemical Name:2-Methylene-3(2H)-furanone
CAS No.:92544-22-4
Molecular Formula:C5H4 O2
Molecular Weight:96.0856
Hs Code.:
DSSTox Substance ID:DTXSID80239038
Nikkaji Number:J2.387.037A
Wikidata:Q83121381
Mol file:92544-22-4.mol

Synonyms:2-MEFUE;2-methylene-3(2H)-furanone

Suppliers and Price of 2-Methylene-3(2H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Methylene-3(2H)-furanone

Chemical Property:

Vapor Pressure:0.0861mmHg at 25°C
Boiling Point:225.5°Cat760mmHg
Flash Point:112.5°C
Density:1.14g/cm³
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:96.021129366
Heavy Atom Count:7
Complexity:144

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=C1C(=O)C=CO1

Technology Process of 2-Methylene-3(2H)-furanone

There total 9 articles about 2-Methylene-3(2H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428903-51-8
2'-deoxy-2'-chloroguanosine-5'-triphosphate

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 92544-22-4
2-methylene-3(2H)-furanone

Guidance literature:: With sodium dithionite; radical S-adenosylmethionine (AdoMet) enzyme; AdoMet; In water; for 5h; Enzymatic reaction;
DOI:10.1021/ja502663k

Reference yield:

: 221092-58-6
9-<3,4-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-trifluoromethanesulfonyl-β-D-arabino-furanosyl>guanine

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 92544-22-4
2-methylene-3(2H)-furanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / N,N-dimethyl-formamide / 20 - 50 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

3.1: trimethyl phosphite / 0.25 h / 50 °C

3.2: 1.5 h / 0 °C

4.1: NDP kinase; guanylate kinase; ATP / water / Enzymatic reaction

5.1: radical S-adenosylmethionine (AdoMet) enzyme; AdoMet; sodium dithionite / water / 5 h / Enzymatic reaction

With trimethyl phosphite; sodium dithionite; guanylate kinase; radical S-adenosylmethionine (AdoMet) enzyme; NDP kinase; AdoMet; tetrabutyl ammonium fluoride; ATP; lithium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja502663k

Reference yield:

: 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-chloro-2'-deoxy-β-D-guanosine

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 92544-22-4
2-methylene-3(2H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

2.1: trimethyl phosphite / 0.25 h / 50 °C

2.2: 1.5 h / 0 °C

3.1: NDP kinase; guanylate kinase; ATP / water / Enzymatic reaction

4.1: radical S-adenosylmethionine (AdoMet) enzyme; AdoMet; sodium dithionite / water / 5 h / Enzymatic reaction

With trimethyl phosphite; sodium dithionite; guanylate kinase; radical S-adenosylmethionine (AdoMet) enzyme; NDP kinase; AdoMet; tetrabutyl ammonium fluoride; ATP; In tetrahydrofuran; water;
DOI:10.1021/ja502663k