2-fluoro-10H-Phenothiazine

Base Information

• Chemical Name: 2-fluoro-10H-Phenothiazine
• CAS No.: 397-58-0
• Molecular Formula: C₁₂H₈FNS
• Molecular Weight: 217.267
• Mol file: 397-58-0.mol

Synonyms:Phenothiazine, 2-fluoro- (6CI,8CI); NSC 403727

Chemical Property of 2-fluoro-10H-Phenothiazine

Chemical Property:

• Vapor Pressure: 2.16E-05mmHg at 25°C
• Boiling Point: 360.8°Cat760mmHg
• Flash Point: 172°C
• PSA: 37.33000
• Density: 1.31g/cm³
• LogP: 4.17190

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-10H-phenothiazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-10H-Phenothiazine

There total 7 articles about 2-fluoro-10H-Phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

thioacetic acid S-(2-acetylamino-phenyl)ester (1204-55-3) + 2-bromo-4-fluoro-1-iodobenzene (202865-73-4) → 2-fluoro-10H-phenothiazine (397-58-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 10h; Inert atmosphere;

DOI:10.1080/00397911.2017.1281959

Reference yield: 72.0%

1,3-Benzothiazole (95-16-9) + 2-bromo-4-fluoro-1-iodobenzene (202865-73-4) → 2-fluoro-10H-phenothiazine (397-58-0)

Guidance literature:

With N-(benzyloxy)-1H-pyrrole-2-carboxamide; copper; caesium carbonate; at 110 ℃; for 14h; Sealed tube;

Reference yield: 62.0%

C13H9FN2O3S → 2-fluoro-10H-phenothiazine (397-58-0)

Guidance literature:

With potassium hydroxide; In ethanol; acetone; for 4h; Heating;

DOI:10.1080/10426500701544557

upstream raw materials:

C₁₂H₉BrFNS

cyclohexanone

2-amino-4-fluorobenzene-1-thiol

1,3-Benzothiazole