Syringolin

Base Information

• Chemical Name: Syringolin
• CAS No.: 212115-96-3
• Molecular Formula: C₂₄H₃₉N₅O₆
• Molecular Weight: 493.604
• Mol file: 212115-96-3.mol

Synonyms:

Chemical Property of Syringolin

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Syringolin

There total 2 articles about Syringolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl (S)-2-(3-((S)-1-((3E,5S,8S,9E)-5-isopropyl-2,7-dioxo-1,6-diazacyclododeca-3,9-dien-8-ylamino)-3-methyl-1-oxobutan-2-yl)ureido)-3-methylbutanoate (1236182-18-5) → Syringolin A (212115-96-3)

Guidance literature:

With formic acid; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol101252y

Reference yield: 92.0%

syringolin A methyl ester (1163728-33-3) → Syringolin A (212115-96-3)

Guidance literature:

syringolin A methyl ester; With aluminum (III) chloride; Ethyl methyl sulfide; at 0 - 20 ℃;

With hydrogenchloride; In methanol; dichloromethane; water;

DOI:10.1021/ol100761z

Reference yield: 79.0%

Syringolin A (212115-96-3) + 2-(2-methoxyethoxy)ethanamine (31576-51-9,80506-64-5,869718-87-6) → SylA-PEG2 (1234145-84-6)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h;

DOI:10.1002/ejoc.201000317

upstream raw materials:

syringolin A methyl ester

tert-butyl (S)-2-(3-((S)-1-((3E,5S,8S,9E)-5-isopropyl-2,7-dioxo-1,6-diazacyclododeca-3,9-dien-8-ylamino)-3-methyl-1-oxobutan-2-yl)ureido)-3-methylbutanoate

Downstream raw materials:

SylA-PEG₂