2-AMINO-5-ETHYL-6-METHYLPYRIMIDIN-4-OL

Base Information

• Chemical Name: 2-AMINO-5-ETHYL-6-METHYLPYRIMIDIN-4-OL
• CAS No.: 28224-69-3
• Molecular Formula: C₇H₁₁N₃O
• Molecular Weight: 153.184
• Hs Code.: 2933599090
• Mol file: 28224-69-3.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-5-ethyl-6-methyl- (8CI,9CI);4(3H)-Pyrimidinone,2-amino-5-ethyl-6-methyl- (7CI);NSC 210935;

Chemical Property of 2-AMINO-5-ETHYL-6-METHYLPYRIMIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0.00584mmHg at 25°C
• Melting Point: 288-289 °C
• Refractive Index: 1.604
• Boiling Point: 273.1 °C at 760 mmHg
• PKA: 10.17±0.50(Predicted)
• Flash Point: 119 °C
• PSA: 71.77000
• Density: 1.29 g/cm³
• LogP: 0.80410

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-ethyl-6-methyl-4-pyrimidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-ETHYL-6-METHYLPYRIMIDIN-4-OL

There total 4 articles about 2-AMINO-5-ETHYL-6-METHYLPYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-ethyl-2-amino-6-methyl-3H-pyrimidin-4-one (28224-69-3)

Guidance literature:

With ammonia; at 150 - 160 ℃;

Reference yield:

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + ethyl 2-ethyl-3-oxobutanoate (607-97-6) → 5-ethyl-2-amino-6-methyl-3H-pyrimidin-4-one (28224-69-3)

Guidance literature:

at 160 ℃;

DOI:10.1021/ja01856a046

Reference yield:

→ 2-amino-5-ethyl-6-methyl-3H-pyrimidin-4-one (28224-69-3)

Guidance literature:

Guanidin, MeCOCH(Et)CO2R;

DOI:10.1248/cpb.18.261

upstream raw materials:

diguanidine carbonate

ethyl 2-ethyl-3-oxobutanoate

Downstream raw materials:

2-Amino-4-chlor-5-ethyl-6-methyl-pyrimidin

Refernces