N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea

Base Information

Chemical Name:N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea
CAS No.:75883-74-8
Molecular Formula:C₂₀H₂₉N₃O₅
Molecular Weight:391.467
Hs Code.:
DSSTox Substance ID:DTXSID90997278
Nikkaji Number:J87.690I
ChEMBL ID:CHEMBL44677

Synonyms:BRN 5161669;Urea, 1-(4,7-dimethoxy-6-(2-piperidinopropoxy)-5-benzofuranyl)-3-methyl-;N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea;75883-74-8;CHEMBL44677;DTXSID90997278;LS-159930;1-[4,7-Dimethoxy-6-(2-piperidinopropoxy)benzofuran-5-yl]-3-methylurea;N-{4,7-Dimethoxy-6-[2-(piperidin-1-yl)propoxy]-1-benzofuran-5-yl}-N'-methylcarbamimidic acid

Suppliers and Price of N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea

Chemical Property:

Vapor Pressure:5.46E-11mmHg at 25°C
Boiling Point:521.9°Cat760mmHg
Flash Point:269.4°C
Density:1.205g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:391.21072103
Heavy Atom Count:28
Complexity:502

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(COC1=C(C2=C(C=CO2)C(=C1NC(=O)NC)OC)OC)N3CCCCC3

Technology Process of N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea

There total 8 articles about N-(4,7-Dimethoxy-6-(2-methyl-2-piperidinoethoxy)-5-benzofuranyl)-N'-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 75884-07-0
4,7-dimethoxy-6-(2-piperidinopropoxy)-5-benzofuranamine

: 624-83-9
methyl isocyanate

: 75883-74-8
N-<4,7-dimethoxy-6-(2-piperidinopropoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: In toluene; for 5h; Ambient temperature;
DOI:10.1021/jm00134a007

Reference yield:

: 52631-79-5
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide

: 75883-74-8
N-<4,7-dimethoxy-6-(2-piperidinopropoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / K₂CO₃ / acetonitrile / 2.5 h / Heating

2: 76 percent / NaBH₄ / ethanol / 1 h / Heating

3: 50 percent / thionyl chloride / benzene / 1 h / Heating

4: 44 percent / NaI / 24 h / 100 °C

5: 59 percent / 2 N HCl / 5 h / Heating

6: 43 percent / toluene / 5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; sodium iodide; In ethanol; toluene; acetonitrile; benzene;
DOI:10.1021/jm00134a007

Reference yield:

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 75883-74-8
N-<4,7-dimethoxy-6-(2-piperidinopropoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / hydroxylamine hydrochloride, conc. NaOH / ethanol; H₂O / 6 h / Heating

2: 75 percent / aq. AcOH, HCl(g) / 0.5 h / 90 °C

3: 69 percent / K₂CO₃ / acetonitrile / 2.5 h / Heating

4: 76 percent / NaBH₄ / ethanol / 1 h / Heating

5: 50 percent / thionyl chloride / benzene / 1 h / Heating

6: 44 percent / NaI / 24 h / 100 °C

7: 59 percent / 2 N HCl / 5 h / Heating

8: 43 percent / toluene / 5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; acetic acid; sodium iodide; In ethanol; water; toluene; acetonitrile; benzene;
DOI:10.1021/jm00134a007