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Technology Process of Tezosentan

Tezosentan

Base Information
  • Chemical Name:Tezosentan
  • CAS No.:180384-57-0
  • Molecular Formula:C27H27N9O6S
  • Molecular Weight:605.633
  • Hs Code.:
  • UNII:64J9J55263
  • DSSTox Substance ID:DTXSID20170956
  • Nikkaji Number:J1.166.144K
  • Wikipedia:Tezosentan
  • Wikidata:Q426203
  • NCI Thesaurus Code:C97358
  • Pharos Ligand ID:Z2RMFC2V8ZWG
  • Metabolomics Workbench ID:149833
  • ChEMBL ID:CHEMBL61780
  • Mol file:180384-57-0.mol
Tezosentan

Synonyms:5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl--pyridin-4-yl)--pyrimidin-4-ylamide;RO 61-0612;RO 610612;tezosentan

Suppliers and Price of Tezosentan
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Tezosentan
  • 100mg
  • $ 14025.00
  • Medical Isotopes, Inc.
  • Tezosentan
  • 100 mg
  • $ 13750.00
  • Matrix Scientific
  • N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide 95+%
  • 1g
  • $ 4725.00
  • Crysdot
  • N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide 95+%
  • 1g
  • $ 1980.00
  • Chemenu
  • N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide 95%
  • 1g
  • $ 1866.00
  • American Custom Chemicals Corporation
  • TEZOSENTAN 95.00%
  • 50MG
  • $ 10106.25
  • American Custom Chemicals Corporation
  • TEZOSENTAN 95.00%
  • 25MG
  • $ 8373.75
  • Alichem
  • N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide
  • 1g
  • $ 1568.00
Total 14 raw suppliers
Chemical Property of Tezosentan
Chemical Property:
  • Vapor Pressure:2.33E-24mmHg at 25°C 
  • Melting Point:198-200° 
  • Boiling Point:761.2°C at 760 mmHg 
  • Flash Point:414.2°C 
  • PSA：208.49000 
  • Density:1.432g/cm3 
  • LogP:4.36370 
  • Storage Temp.:2-8°C 
  • XLogP3:2.4
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:14
  • Rotatable Bond Count:12
  • Exact Mass:605.18050079
  • Heavy Atom Count:43
  • Complexity:962
Purity/Quality:

99% *data from raw suppliers

Tezosentan *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)C1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=NNN=N4)OCCO)OC5=CC=CC=C5OC
  • Recent ClinicalTrials:Tezosentan in the Treatment of Acute Heart Failure
  • Recent EU Clinical Trials:Multicenter, open-label, non-comparative, proof-of-concept, phase 2a study to evaluate the effect of a single infusion of tezosentan on pulmonary vascular resistance in patients with stable, chronic pulmonary arterial hypertension, currently not treated with endothelin receptor antagonists, phosphodiesterase-5 inhibitors or prostacyclines
  • Uses A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900). Tezosentan is used in the treatment of congestive heart failure. A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900). It is used in the treatment of congestive heart failure.
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