Chemical Property of Paxilline
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:1.02E-17mmHg at 25°C
- Melting Point:252ºC
- Boiling Point:648.8 °C at 760 mmHg
- Flash Point:346.2 °C
- PSA：82.55000
- Density:1.31 g/cm3
- LogP:3.95670
- Storage Temp.:2-8°C
- Solubility.:Soluble in DMSO, acetone or chloroform.
- XLogP3:3.5
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:435.24095853
- Heavy Atom Count:32
- Complexity:868
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Paxilline *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T,Xn,F
- Statements:
23/24/25-36/37/38-41-36-20/21/22-11
- Safety Statements:
26-36/37/39-45-36/37-16
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
- Isomeric SMILES:C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)O
-
Description
A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium
paxilli. The structure has been confirmed by X-ray crystallography. The crystals
are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and
c = 7.70 A. Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM). It also enhances the binding of charybdotoxin , a peptidyl neurotoxin, to BKCa channels. Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.
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Uses
Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor. Potent blocker of high-conductance calcium-activated potassium (BKCa) channels
