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Technology Process of CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE

Base Information
  • Chemical Name:CLOZAPINE N-OXIDE
  • CAS No.:34233-69-7
  • Molecular Formula:C18H19 Cl N4 O
  • Molecular Weight:342.82
  • Hs Code.:29335990
  • Mol file:34233-69-7.mol
CLOZAPINE N-OXIDE

Synonyms:5H-Dibenzo[b,e][1,4]diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide (8CI); Clozapine N-oxide

Suppliers and Price of CLOZAPINE N-OXIDE
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Clozapine N-oxide
  • 1mg
  • $ 45.00
  • Tocris
  • Clozapine N-oxide ≥99%(HPLC)
  • 50
  • $ 683.00
  • Tocris
  • Clozapine N-oxide ≥99%(HPLC)
  • 10
  • $ 163.00
  • Sigma-Aldrich
  • Clozapine N-oxide solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • 1 mL
  • $ 122.00
  • Sigma-Aldrich
  • Clozapine N-oxide solution
  • 125-1ml
  • $ 118.00
  • Sigma-Aldrich
  • Clozapine N-oxide
  • 5mg
  • $ 194.00
  • Medical Isotopes, Inc.
  • Clozapine N-oxide
  • 1 mg
  • $ 190.00
  • DC Chemicals
  • Clozapine N-oxide >98%
  • 1 g
  • $ 1450.00
  • ChemScene
  • Clozapine N-oxide 99.98%
  • 50mg
  • $ 420.00
  • ChemScene
  • Clozapine N-oxide 99.98%
  • 100mg
  • $ 672.00
Total 34 raw suppliers
Chemical Property of CLOZAPINE N-OXIDE
Chemical Property:
  • Vapor Pressure:1.57E-11mmHg at 25°C 
  • Melting Point:190-248°C 
  • Boiling Point:517.4°Cat760mmHg 
  • PKA:6.86±0.20(Predicted) 
  • Flash Point:266.7°C 
  • PSA：57.06000 
  • Density:1.36g/cm3 
  • LogP:3.20560 
  • Storage Temp.:-20°C Freezer, Under Inert Atmosphere 
  • Solubility.:Soluble in DMSO. 
Purity/Quality:

99%, *data from raw suppliers

Clozapine N-oxide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xn,T,F 
  • Statements: 22-36/37/38-39/23/24/25-23/24/25-11 
  • Safety Statements: 26-36-45-36/37-16-7 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Description Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
  • Uses Clozapine N-oxide has been used:for the activation of human M4 muscarinic (hM4Di) in primary motor cortexfor inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic micein behavioral testing in mice and for stimulating (HEK293) cells A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
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