2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide

Base Information

• Chemical Name: 2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide
• CAS No.: 25288-09-9
• Molecular Formula: C13H11 Cl N2 O2
• Molecular Weight: 262.696
• NSC Number: 160930
• DSSTox Substance ID: DTXSID10948126
• Wikidata: Q82925915
• Mol file: 25288-09-9.mol

Synonyms:25288-09-9;NSC160930;CBKinase1_000339;CBKinase1_012739;Cambridge id 5541030;2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide;Oprea1_300618;Oprea1_633649;DTXSID10948126;STK015933;AKOS003238807;NSC-160930;AB00088133-01;SR-01000212162;SR-01000212162-1;2-(4-Chlorophenoxy)-N-(pyridin-3-yl)ethanimidic acid;BRD-K17132113-001-01-9;Z31791686;2-(4-CHLOROPHENOXY)-N~1~-(3-PYRIDYL)ACETAMIDE

Chemical Property of 2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide

Chemical Property:

• Vapor Pressure: 9.84E-10mmHg at 25°C
• Boiling Point: 489.6°Cat760mmHg
• Flash Point: 249.9°C
• Density: 1.339g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 262.0509053
• Heavy Atom Count: 18
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)NC(=O)COC2=CC=C(C=C2)Cl

Technology Process of 2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide

There total 3 articles about 2-(4-chlorophenoxy)-N-(pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-(pyridine-3-yl)acetamide (78205-18-2) + 4-chloro-phenol (106-48-9,82344-39-6) → 2-(4-chlorophenoxy)-N-pyridin-3-ylacetamide (25288-09-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.5012/bkcs.2013.34.2.394

Reference yield:

pyridin-3-ylamine (462-08-8) → 2-(4-chlorophenoxy)-N-pyridin-3-ylacetamide (25288-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 0 - 20 °C

2: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.5012/bkcs.2013.34.2.394

Reference yield:

→ 2-(4-chlorophenoxy)-N-pyridin-3-ylacetamide (25288-09-9)

Guidance literature:

4-Chlor-phenoxy-acetylchlorid, 3-Amino-pyridin;

DOI:10.1021/jm00304a026

upstream raw materials:

pyridin-3-ylamine

2-chloro-N-(pyridine-3-yl)acetamide

4-chloro-phenol

Downstream raw materials:

N-(4-chlorophenyl)pyridin-3-amine

2-(4-Chloro-phenoxy)-N-propyl-N-pyridin-3-yl-acetamide

N-Butyl-2-(4-chloro-phenoxy)-N-pyridin-3-yl-acetamide

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