4-bromo-9H-fluorene

Base Information

• Chemical Name: 4-bromo-9H-fluorene
• CAS No.: 19459-33-7
• Molecular Formula: C13H9Br
• Molecular Weight: 245.118
• Hs Code.: 2903999090
• NSC Number: 171607
• DSSTox Substance ID: DTXSID30305757
• Wikidata: Q82052488
• Mol file: 19459-33-7.mol

Synonyms:4-bromo-9H-fluorene;19459-33-7;9H-Fluorene, 4-bromo-;4-bromofluorene;4-bromo-fluorene;NSC171607;4-brom-9H-fluoren;9H-Fluorene,4-bromo-;SCHEMBL789190;DTXSID30305757;XFWGSCNZZYLJJG-UHFFFAOYSA-N;AKOS015906860;NSC-171607;FT-0719749

Chemical Property of 4-bromo-9H-fluorene

Chemical Property:

• Vapor Pressure: 8.99E-05mmHg at 25°C
• Melting Point: 165 °C
• Boiling Point: 350.3°Cat760mmHg
• Flash Point: 166.8°C
• PSA: 0.00000
• Density: 1.489g/cm³
• LogP: 4.02030
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 243.98876
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-9H-fluorene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C3=CC=CC=C31)C(=CC=C2)Br

Technology Process of 4-bromo-9H-fluorene

There total 11 articles about 4-bromo-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-bromo-2,7-di(tert-butyl)-9H-fluorene (91611-97-1) → 4-bromo-9H-fluorene (19459-33-7)

Guidance literature:

aluminium trichloride; In benzene; at 50 ℃; for 6h;

DOI:10.1055/s-1984-30835

Reference yield: 25.0%

2-bromo-2'-(cyclohepta-2,4,6-trien-1-yl)-1,1'-biphenyl (1528732-82-2) → 4-bromo-9H-fluorene (19459-33-7)

Guidance literature:

With (acetonitrile)[2-di-tert-butyl(2′,4′,4′,6'-triisopropylbiphenyl)phosphine]gold(I) hexafluoroantimonate; In 1,2-dichloro-ethane; at 120 ℃; for 8h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ja411626v

Reference yield:

2,7-di-tert-butyl-9H-fluorene (58775-05-6) → 4-bromo-9H-fluorene (19459-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / iron, bromine / CCl₄ / 3 h / 15 - 20 °C

2: 45 percent / AlCl₃ / benzene / 6 h / 50 °C

With aluminium trichloride; bromine; iron; In tetrachloromethane; benzene;

DOI:10.1246/bcsj.59.97

upstream raw materials:

4-Aminofluorene

4-bromo-fluoren-9-ol

4-bromo-2,7-di(tert-butyl)-9H-fluorene

9H-fluorene

Downstream raw materials:

4-bromo-9H-fluorene-9-one

4-bromophenanthrene

4-Brom-fluoren-9-carbonsaeure