Technology Process of (1R,2R,5R,8S,9S,10R,11R)-5-hydroxy-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadecane-9-carboxylic acid
There total 7 articles about (1R,2R,5R,8S,9S,10R,11R)-5-hydroxy-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadecane-9-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
Yields of byproduct given;
1.) reflux, 16 h, 2.) 18 deg C, 3 d;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 16 mg / tri-n-butylstannane, 2,2'-azobis(2-methylpropionitrile) / toluene / Heating
2: 47 mg / 2M NaOH / methanol / 1.) reflux, 16 h, 2.) 18 deg C, 3 d
With
sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
methanol; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 mg / tri-n-butylstannane, 2,2'-azobis(2-methylpropionitrile) / benzene / 1.5 h / Heating
2: 47 mg / 2M NaOH / methanol / 1.) reflux, 16 h, 2.) 18 deg C, 3 d
With
sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
methanol; benzene;
