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alpha-GalCer

Base Information Edit
  • Chemical Name:alpha-GalCer
  • CAS No.:158021-47-7
  • Molecular Formula:C50H99NO9
  • Molecular Weight:858.337
  • Hs Code.:
  • UNII:WX671898JF
  • DSSTox Substance ID:DTXSID40935847
  • Nikkaji Number:J671.943K
  • Wikipedia:Alpha-Galactosylceramide
  • Wikidata:Q27105159
  • NCI Thesaurus Code:C1720
  • Metabolomics Workbench ID:52756
  • ChEMBL ID:CHEMBL384200
  • Mol file:158021-47-7.mol
alpha-GalCer

Synonyms:KRN 7000;KRN 7000, 1S-(1R*,2R*,3S*)-beta-D-galacto isomer;KRN-7000;KRN7000

Suppliers and Price of alpha-GalCer
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • KRN7000
  • 2mg
  • $ 460.00
  • TCI Chemical
  • α-Galactosylceramide >95.0%(HPLC)
  • 1mg
  • $ 218.00
  • Sigma-Aldrich
  • (2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol ≥95% (TLC)
  • 1mg
  • $ 889.00
  • Cayman Chemical
  • KRN 7000 ≥96%
  • 1mg
  • $ 209.00
  • Cayman Chemical
  • KRN 7000 ≥96%
  • 250μg
  • $ 99.00
  • Biosynth Carbosynth
  • a-Galactosylceramide
  • 20 mg
  • $ 3600.00
  • Biosynth Carbosynth
  • a-Galactosylceramide
  • 10 mg
  • $ 2100.00
  • Biosynth Carbosynth
  • a-Galactosylceramide
  • 5 mg
  • $ 1250.00
  • Biosynth Carbosynth
  • a-Galactosylceramide
  • 2 mg
  • $ 560.00
  • Biosynth Carbosynth
  • a-Galactosylceramide
  • 1 mg
  • $ 295.00
Total 13 raw suppliers
Chemical Property of alpha-GalCer Edit
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:125-130°C 
  • Boiling Point:939.8°Cat760mmHg 
  • PKA:12.92±0.70(Predicted) 
  • Flash Point:522.2°C 
  • PSA:168.94000 
  • Density:1.04g/cm3 
  • LogP:10.87390 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:Pyridine (Slightly, Heated) 
  • XLogP3:16
  • Hydrogen Bond Donor Count:7
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:44
  • Exact Mass:857.73198374
  • Heavy Atom Count:60
  • Complexity:928
Purity/Quality:

98%min *data from raw suppliers

KRN7000 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O
  • Isomeric SMILES:CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O
  • Recent ClinicalTrials:RGI-2001 for the Prevention of Acute Graft-vs-Host Disease in Subjects Following Allogeneic Hematopoietic Stem Cell Transplantation
  • Recent NIPH Clinical Trials:A randomized phase II trial of adjuvant immunotherapy with alpha-GalactosylCeramide-pulsed dendritic cells for advanced oropharyngeal and hypopharyngeal cancer following standard therapy
  • Description KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
  • Uses Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
Technology Process of alpha-GalCer

There total 64 articles about alpha-GalCer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogen; palladium; In ethyl acetate; at 20 ℃; for 10h;
DOI:10.1021/jo0201530
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