5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-

Base Information

Chemical Name:5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-
CAS No.:84339-00-4
Molecular Formula:C₁₇H₁₆FN₃O₃S
Molecular Weight:361.397
Hs Code.:
DSSTox Substance ID:DTXSID90233300
Nikkaji Number:J506.883E
Wikidata:Q83114759
Mol file:84339-00-4.mol

Synonyms:84339-00-4;5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-;7-Fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo(3,2-a)quinoline-4-carboxylic acid;C17H16FN3O3S;SCHEMBL10741443;DTXSID90233300;C17-H16-F-N3-O3-S;LS-152167;5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid,7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-;7-Fluoro-8-(4-methylpiperazin-1-yl)-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acid

Suppliers and Price of 5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5H-THIAZOLO(3,2-A)QUINOLINE-4-CARBOXYLIC ACID, 7-FLUORO-8-(4-METHYL-1-PIPERAZINYL)-5-OXO- 95.00%
5MG
$ 501.92

Total 0 raw suppliers

Chemical Property of 5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-

Chemical Property:

Vapor Pressure:2.93E-13mmHg at 25°C
Boiling Point:557.4°C at 760 mmHg
Flash Point:290.9°C
PSA：93.50000
Density:1.58g/cm³
LogP:2.10620
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:361.08964072
Heavy Atom Count:25
Complexity:660

Purity/Quality:: 5H-THIAZOLO(3,2-A)QUINOLINE-4-CARBOXYLIC ACID, 7-FLUORO-8-(4-METHYL-1-PIPERAZINYL)-5-OXO- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=C(C=C3C(=C2)N4C=CSC4=C(C3=O)C(=O)O)F

Technology Process of 5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-

There total 10 articles about 5H-Thiazolo(3,2-a)quinoline-4-carboxylic acid, 7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 109-01-3
1-methyl-piperazine

: 84338-98-7
8-chloro-7-fluoro-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

: 110236-81-2
8-chloro-7-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

: 84339-00-4
7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: In pyridine; for 75h; Heating;
DOI:10.1002/jhet.5570290514

Reference yield:

: 109-01-3
1-methyl-piperazine

: 84338-98-7
8-chloro-7-fluoro-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

: 84339-00-4
7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: With pyridine; In water;

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 84339-00-4
7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 0 °C

2: triethylamine, ethyl chloroformate / CHCl₃ / 3.5 h / Ambient temperature

3: 1.) sodium hydride / 1.) THF, RT, 1 h, 2.) THF, RT, 1 h

4: dimethylformamide / 2 h / Ambient temperature

5: diphenyl ether / 0.2 h / 250 °C

6: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature

7: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min.

8: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating

9: 52 percent / pyridine / 75 h / Heating

With sodium hydroxide; trifluorormethanesulfonic acid; water; chloroformic acid ethyl ester; sodium hydride; potassium hydrogencarbonate; methoxybenzene; triethylamine; trifluoroacetic acid; In pyridine; diphenylether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570290514