Cyclopentaneethanol, 2-hydroxy-1-methyl-5-(1,2,3,4-tetrahydro-6-methox y-2-naphthalenyl)-, (1S-(1-alpha,2-beta,5-beta(S*)))-

Base Information

• Chemical Name: Cyclopentaneethanol, 2-hydroxy-1-methyl-5-(1,2,3,4-tetrahydro-6-methox y-2-naphthalenyl)-, (1S-(1-alpha,2-beta,5-beta(S*)))-
• CAS No.: 53940-77-5
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 53940-77-5.mol

Synonyms:9,11-Seco-11-hydroxyestradiol3-methyl ether

Chemical Property of Cyclopentaneethanol, 2-hydroxy-1-methyl-5-(1,2,3,4-tetrahydro-6-methox y-2-naphthalenyl)-, (1S-(1-alpha,2-beta,5-beta(S*)))-

Chemical Property:

• Vapor Pressure: 2.25E-09mmHg at 25°C
• Boiling Point: 463.1°Cat760mmHg
• Flash Point: 233.9°C
• PSA: 49.69000
• Density: 1.114g/cm³
• LogP: 2.95970

Purity/Quality:

97% ^*data from raw suppliers

(1S-(1-ALPHA,2-BETA,5-BETA(S*)))-2-HYDROXY-1-METHYL-5-(1,2,3,4-TETRAHYDRO-6-METHOX Y-2-NAPHTHALENYL)-CYCLOPENTANEETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentaneethanol, 2-hydroxy-1-methyl-5-(1,2,3,4-tetrahydro-6-methox y-2-naphthalenyl)-, (1S-(1-alpha,2-beta,5-beta(S*)))-

There total 5 articles about Cyclopentaneethanol, 2-hydroxy-1-methyl-5-(1,2,3,4-tetrahydro-6-methox y-2-naphthalenyl)-, (1S-(1-alpha,2-beta,5-beta(S*)))- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17β-acetoxy-3-methoxy-9-oxo-9,11-seco-1,3,5(10)-estratrien-11-oic acid (1247-46-7) → 11-hydroxy-9,11-seco-17β-estradiol 3-methyl ether (53940-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, aq. HCl / Pd-C

2: LiAlH₄

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00241a026

Reference yield:

methyl 17β-hydroxy-3-methoxy-9,11-seco-estra-1,3,5(10)-triene-11-carboxylate (56502-05-7) → 11-hydroxy-9,11-seco-17β-estradiol 3-methyl ether (53940-77-5)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jm00241a026

Reference yield:

→ 9,11-Seco-11-hydroxyestradiol-3-methyl ether (53940-77-5,58342-07-7,116262-68-1)

Guidance literature:

Saeur (3b), LiAlH4;

DOI:10.1021/jo00894a005

upstream raw materials:

methyl 17β-hydroxy-3-methoxy-9,11-seco-estra-1,3,5(10)-triene-11-carboxylate

17β-acetoxy-3-methoxy-9-oxo-9,11-seco-1,3,5(10)-estratrien-11-oic acid

Refernces

• 1、 Singh, Ashvani K.,Lal, Kasturi,Prakash, Om,Agarwal, A. K.,Ray, Suprabhat. "Facile Formation of 9,11-Secoestrane-11,17-oxides from Corresponding 9,11-Secoestranes". . p. 839 - 842. Retrieved 2007/10/02.
• 2、 Dygos,Chinn. "Synthesis of 9,11 secoestradiol 3 methyl ether". . p. 685 - 687. Retrieved 2007/10/10.