5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione
CAS No.:98736-93-7
Molecular Formula:C₁₂H₁₈N₂O₄
Molecular Weight:254.286
Hs Code.:
DSSTox Substance ID:DTXSID60913107
ChEMBL ID:CHEMBL353639
Mol file:98736-93-7.mol

Synonyms:5-ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione;carbocyclic 2'-deoxy-5-ethyluridine;carbocyclic 5-ethyl-2'-deoxyuridine

Suppliers and Price of 5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：95.58000
Density:1.315g/cm³
LogP:-0.18440
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:254.12665706
Heavy Atom Count:18
Complexity:394

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=CN(C(=O)NC1=O)C2CC(C(C2)O)CO

Technology Process of 5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione

There total 10 articles about 5-Ethyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 98736-92-6
C₂₆H₂₆N₂O₆

: 98736-93-7
(+/-)-5-ethyl-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-22,4(1H,3H)-pyrimidinedione

Guidance literature:: With ammonia; for 72h; Ambient temperature;
DOI:10.1021/jm00151a013

Reference yield: 63.0%

: 98736-95-9
C-5-ethynyl-2'-deoxyuridine

: 98736-93-7
(+/-)-5-ethyl-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-22,4(1H,3H)-pyrimidinedione

Guidance literature:: With quinoline; hydrogen; Lindlar's catalyst; In acetone; for 0.333333h; under 760 Torr;
DOI:10.1021/jm00151a013

Reference yield:

: 62102-28-7
(+/-)-1-<(1β,3α,4β)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 98736-93-7
(+/-)-5-ethyl-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-22,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / pyridine / 21 h / Ambient temperature

2: iodine monochloride / CH₂Cl₂ / 3 h / Heating

3: 75 percent / (Ph₃P)2PdCl₂, CuI, triethylamine / 3 h / 50 °C

4: 61 percent / NaOCH₃ / methanol / Ambient temperature

5: 63 percent / H₂, quinoline / 5percent Pd/CaCO₃/Pb / acetone / 0.33 h / 760 Torr

With pyridine; quinoline; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; sodium methylate; Iodine monochloride; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; acetone;
DOI:10.1021/jm00151a013