Benzoic acid,4-[[4-(1,1-dimethylethyl)benzoyl]amino]-

Base Information

• Chemical Name: Benzoic acid,4-[[4-(1,1-dimethylethyl)benzoyl]amino]-
• CAS No.: 116233-06-8
• Molecular Formula: C18H19 N O3
• Molecular Weight: 297.354
• Mol file: 116233-06-8.mol

Synonyms:Am 550

Chemical Property of Benzoic acid,4-[[4-(1,1-dimethylethyl)benzoyl]amino]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid,4-[[4-(1,1-dimethylethyl)benzoyl]amino]-

There total 6 articles about Benzoic acid,4-[[4-(1,1-dimethylethyl)benzoyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C25H25NO3 → 4-(4-(tert-butyl)benzamido)benzoic acid (116233-06-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.9b00471

Reference yield: 88.0%

ethyl 4-(4-(tert-butyl)benzamido)benzoate (127442-14-2) → 4-(4-(tert-butyl)benzamido)benzoic acid (116233-06-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 2.5h;

DOI:10.1016/j.ejmech.2020.112411

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-(4-(tert-butyl)benzamido)benzoic acid (116233-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: dichlorotriphenylphosphorane / chloroform / 0.25 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; caesium carbonate; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.9b00471

upstream raw materials:

benzyl 4-aminobenzoate

4-amino-benzoic acid

ethyl 4-(4-(tert-butyl)benzamido)benzoate

p-aminoethylbenzoate

Refernces

• 1、 Bukhari, Shazreh,Cabral, Aaron D.,Gawel, Justyna M.,Gunning, Patrick T.,Israelian, Johan,Manaswiyoungkul, Pimyupa,Nawar, Nabanita,Olaoye, Olasunkanmi O.,Radu, Tudor B.,Raouf, Yasir S.,Sedighi, Abootaleb,Shouksmith, Andrew E.,Sina, Diana,Toutah, Krimo,de Araujo, Elvin D.. "PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia". . . Retrieved 2020/07/03.
• 2、 -. "Pharmaceutical compositions containing phenylamides". . . Retrieved 2008/06/13.