1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-
CAS No.:131338-52-8
Molecular Formula:C₂₃H₁₅N₃O₄
Molecular Weight:397.39
Hs Code.:
DSSTox Substance ID:DTXSID00157008
Wikidata:Q83025136

Synonyms:BRN 4768515;1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-;2-((3,4-Dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-1H-isoindole-1,3(2H)-dione;131338-52-8;DTXSID00157008;LS-84558

Suppliers and Price of 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-

Chemical Property:

Vapor Pressure:1.32E-17mmHg at 25°C
Boiling Point:652.1°Cat760mmHg
Flash Point:348.2°C
Density:1.44g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:397.10625597
Heavy Atom Count:30
Complexity:734

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)O

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)-

There total 3 articles about 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxyphenyl)-4-oxo-2-quinazolinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 123-30-8
4-amino-phenol

: 97118-79-1
2-(4-Oxo-4H-benzo[d][1,3]oxazin-2-ylmethyl)-isoindole-1,3-dione

: 131338-52-8
2-[3-(4-Hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: With pyridine; Heating;

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 131338-52-8
2-[3-(4-Hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

With pyridine;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 131338-52-8
2-[3-(4-Hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

With pyridine;