N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamide

Base Information

• Chemical Name: N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamide
• CAS No.: 93-31-2
• Molecular Formula: C22H29 N O5
• Molecular Weight: 387.476
• Hs Code.: 2924299090
• European Community (EC) Number: 202-238-2
• DSSTox Substance ID: DTXSID80918795
• Nikkaji Number: J182.093A
• Mol file: 93-31-2.mol

Synonyms:EINECS 202-238-2;93-31-2;N-[2-(3,4-DIMETHOXYPHENYL)-1-METHYLETHYL]-4-ETHOXY-3-METHOXYPHENYLACETAMIDE;N-(2-(3,4-Dimethoxyphenyl)-1-methylethyl)-4-ethoxy-3-methoxyphenylacetamide;Benzeneacetamide, N-(2-(3,4-dimethoxyphenyl)-1-methylethyl)-4-ethoxy-3-methoxy-;Benzeneacetamide, N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxy-;DTXSID80918795;N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamid;N-[1-(3,4-Dimethoxyphenyl)propan-2-yl]-2-(4-ethoxy-3-methoxyphenyl)ethanimidic acid;N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxybenzeneacetamide

Chemical Property of N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamide

Chemical Property:

• Vapor Pressure: 1.52E-14mmHg at 25°C
• Boiling Point: 585.4°C at 760 mmHg
• Flash Point: 307.8°C
• PSA: 69.51000
• Density: 1.235g/cm³
• LogP: 4.24130
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 387.20457303
• Heavy Atom Count: 28
• Complexity: 460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)CC(=O)NC(C)CC2=CC(=C(C=C2)OC)OC)OC

Technology Process of N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamide

There total 1 articles about N-[2-(3,4-Dimethoxyphenyl)-1-methylethyl]-4-ethoxy-3-methoxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (4-ethoxy-3-methoxy-phenyl)-acetic acid-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamide] (93-31-2)

Guidance literature:

/BRN= 2182331/;

DOI:10.1021/ja01138a051

Reference yield:

(4-ethoxy-3-methoxy-phenyl)-acetic acid-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamide] (93-31-2) → vasodilator (147-27-3)

Guidance literature:

DOI:10.1021/ja01138a051

Reference yield:

(4-ethoxy-3-methoxy-phenyl)-acetic acid-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamide] (93-31-2) → 1-(4-ethoxy-3-methoxy-benzyl)-6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride (111211-21-3)

Guidance literature:

With trichlorophosphate; benzene;

Downstream raw materials:

1-(4-ethoxy-3-methoxy-benzyl)-6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride

vasodilator

Refernces

Chemical synthesis of UB-AMC via ligation of peptide hydrazides

10.1007/s11426-013-4885-x

The study presents an efficient method for the chemical synthesis of Ub-AMC, a probe used for fluorescence-based analysis of deubiquitinating enzyme (DUB) activity, through the ligation of peptide hydrazides. The researchers assembled three peptide segments (Ub1, Ub2, and Ub3) via N-to-C sequential ligation and converted the product to Ub-AMC using TCEP-mediated desulfurization. The synthetic Ub-AMC was shown to have expected biological functions, as demonstrated by its DUB activity. Key chemicals used in the study include Fmoc-protected amino acids for peptide synthesis, reagents like HBTU, DIC, and POCl3 for peptide coupling and activation, and 7-amino-4-methylcoumarin for the synthesis of the AMC group. Other chemicals such as TFA, TIPS, and various solvents were used in the purification and cleavage steps. The purpose of these chemicals was to facilitate the synthesis, purification, and characterization of the Ub-AMC probe, which is crucial for biomedical research and the development of DUB inhibitors.

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