2-TRIFLUOROMETHYL-ADENOSINE

Base Information

• Chemical Name: 2-TRIFLUOROMETHYL-ADENOSINE
• CAS No.: 4627-40-1
• Molecular Formula: C₁₁H₁₂F₃N₅O₄
• Molecular Weight: 335.243
• Mol file: 4627-40-1.mol

Synonyms:2-Trifluoromethyladenosine;NSC 327195

Chemical Property of 2-TRIFLUOROMETHYL-ADENOSINE

Chemical Property:

• Vapor Pressure: 2.41E-09mmHg at 25°C
• Boiling Point: 462.3°Cat760mmHg
• Flash Point: 233.4°C
• PSA: 139.54000
• Density: 2.11g/cm³
• LogP: -0.38000

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TRIFLUOROMETHYL-ADENOSINE

There total 4 articles about 2-TRIFLUOROMETHYL-ADENOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N6,2′,3′,5′-tri-O-tetraacetyl-2-trifluoromethyladenosine → 2-Trifluoromethyl-adenosine (4627-40-1)

Guidance literature:

With methylamine; In ethanol; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.joc.9b03198

Reference yield: 70.0%

2-iodoadenosine (35109-88-7) + (Trifluoromethyl)zinc bromide (97571-13-6) → 2-Trifluoromethyl-adenosine (4627-40-1)

Guidance literature:

With copper(I) bromide; In N,N-dimethyl-formamide; Heating;

DOI:10.1039/c39890000878

Reference yield: 63.0%

copper bromide + 2-iodoadenosine (35109-88-7) + (Trifluoromethyl)zinc bromide (97571-13-6) → 2-Trifluoromethyl-adenosine (4627-40-1)

Guidance literature:

In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

2-iodoadenosine

(Trifluoromethyl)zinc bromide

Downstream raw materials:

2',3'-Dideoxy-2-(trifluoromethyl)adenosine

Refernces

• 1、 Nair, Vasu,Purdy, David F.,Sells, Todd B.. "Synthesis of Congeners of Adenosine Resistant to Deamination by Adenosine Deaminase". . p. 878 - 879. Retrieved 1989.
• 2、 -. "Stable congener of 2',3'-dideoxyadenosine". . . Retrieved 2008/06/13.