Chemical Property of Rhein 8-Glucoside
Chemical Property:
- Melting Point:>245°C (dec.)
- PSA：191.05000
- LogP:-0.95550
- Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
- Solubility.:DMSO (Slightly)
- XLogP3:0.4
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:4
- Exact Mass:446.08491139
- Heavy Atom Count:32
- Complexity:756
- Purity/Quality:
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HPLC≥98% *data from raw suppliers
Rhein 8-glucoside *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2=O)C=C(C=C4O)C(=O)O
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Uses
Rhein 8-Glucoside has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine
Kinase 1B) in vitro. It is an analog of Rhein (318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resour
ce: endophytic fungi from medicinal plants. Rhein 8-Glucoside has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (R318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.
