(3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Base Information

Chemical Name:(3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate
CAS No.:145631-07-8
Molecular Formula:C₂₉H₄₅N₃O₅
Molecular Weight:515.693
Hs Code.:
Mol file:145631-07-8.mol

(3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Synonyms:Carbamicacid,[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-,tetrahydro-3-furanyl ester, [3S-[2[1R*(R*),2S*],3a,4ab,8ab]]-; L 702157

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Chemical Property of (3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Chemical Property:

Vapor Pressure:7.96E-22mmHg at 25°C
Boiling Point:721.1°Cat760mmHg
Flash Point:389.9°C
Density:1.18g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

There total 10 articles about (3S)-tetrahydrofuran-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136465-89-9
(2S)-2-[1'(S)-1-azido-2-phenylethyl]oxirane

: 145631-07-8
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (R)-(tetrahydro-furan-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / propan-2-ol / 12 h / 80 °C

2: 98 percent / H₂, acetic acid / 10percent palladium on charcoal / tetrahydrofuran; methanol / 12 h

3: triethylamine / CH₂Cl₂ / 12 h / 23 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00054a015

Reference yield:

: 136465-89-9
(2S)-2-[1'(S)-1-azido-2-phenylethyl]oxirane

: 145631-07-8
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (S)-(tetrahydro-furan-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / propan-2-ol / 12 h / 80 °C

2: 98 percent / H₂, acetic acid / 10percent palladium on charcoal / tetrahydrofuran; methanol / 12 h

3: triethylamine / CH₂Cl₂ / 12 h / 23 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00054a015

Reference yield:

: 128019-40-9,149510-73-6,136465-81-1,168899-60-3
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

: 145631-07-8
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (R)-(tetrahydro-furan-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / propan-2-ol / 12 h / 80 °C

2: 98 percent / H₂, acetic acid / 10percent palladium on charcoal / tetrahydrofuran; methanol / 12 h

3: triethylamine / CH₂Cl₂ / 12 h / 23 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00054a015