4-(4-Chloro-phenyl)-thiazol-2-ol

Base Information

• Chemical Name: 4-(4-Chloro-phenyl)-thiazol-2-ol
• CAS No.: 2103-98-2
• Molecular Formula: C9H6ClNOS
• Molecular Weight: 211.672
• Hs Code.: 2934100090
• Mol file: 2103-98-2.mol

Synonyms:2-Thiazolol,4-(p-chlorophenyl)- (7CI,8CI);4-Thiazolin-2-one, 4-(p-chlorophenyl)- (6CI);4-(4-Chlorophenyl)-2(3H)-thiazolone;NSC 55674;

Chemical Property of 4-(4-Chloro-phenyl)-thiazol-2-ol

Chemical Property:

• Vapor Pressure: 2.58E-07mmHg at 25°C
• Melting Point: 222-226 °C
• Refractive Index: 1.655
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• PSA: 61.10000
• Density: 1.428 g/cm³
• LogP: 2.75680

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Chlorophenyl)-1,3-thiazol-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-(4-Chloro-phenyl)-thiazol-2-ol

There total 7 articles about 4-(4-Chloro-phenyl)-thiazol-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(4-chloro-phenyl)-2-thiocyanato-ethanone (19339-59-4) → 4-(4-chlorophenyl)-2,3-dihydro-2-oxo-thiazole (2103-98-2)

Guidance literature:

With sulfuric acid; acetic acid; In water; at 60 ℃; for 2h; Heating / reflux;

Reference yield: 65.0%

Thiocarbonic acid S-[2-(4-chloro-phenyl)-2-oxo-ethyl] ester O-methyl ester (65398-74-5) → 4-(4-chlorophenyl)-2,3-dihydro-2-oxo-thiazole (2103-98-2)

Guidance literature:

With ammonium acetate; acetic acid; at 80 ℃; for 2h;

DOI:10.1021/jo00029a060

Reference yield:

O-ethyl thiocarbamate (625-57-0) + 4-chlorobenzoylmethyl bromide (536-38-9) → 4-(4-chlorophenyl)-2,3-dihydro-2-oxo-thiazole (2103-98-2)

Guidance literature:

With ethanol;

DOI:10.1021/ja01552a046

upstream raw materials:

1-(4-chloro-phenyl)-2-thiocyanato-ethanone

O-ethyl thiocarbamate

4-chlorobenzoylmethyl bromide

Thiocarbonic acid S-[2-(4-chloro-phenyl)-2-oxo-ethyl] ester O-methyl ester

Downstream raw materials:

C₃₃H₃₀Cl₂N₂O₇S₂

Refernces

• 1、 Haywood, Tom,Cesarec, Sara,Kealey, Steven,Plisson, Christophe,Miller, Philip W.. "Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling". supporting information. p. 1311 - 1314. Retrieved 2018/08/28.
• 2、 -. "TETRAZOLINONE COMPOUNDS AND ITS USE". Paragraph 0465. . Retrieved 2013/11/18.