Boc-Ser-OH.DCHA

Base Information

• Chemical Name: Boc-Ser-OH.DCHA
• CAS No.: 10342-06-0
• Molecular Formula: C20H38N2O5
• Molecular Weight: 386.532
• European Community (EC) Number: 233-742-0
• DSSTox Substance ID: DTXSID80145827
• Mol file: 10342-06-0.mol

Synonyms:Boc-Ser-OH.DCHA;10342-06-0;N-(tert-Butoxycarbonyl)-L-serine, compound with dicyclohexylamine (1:1);N-[tert-butoxycarbonyl]-L-serine, compound with dicyclohexylamine (1;N-cyclohexylcyclohexanamine;(2s)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic Acid;EINECS 233-742-0;Boc-Ser-OH?DCHA;DTXSID80145827;NS00086494

Chemical Property of Boc-Ser-OH.DCHA

Chemical Property:

• Vapor Pressure: 5.72E-15mmHg at 25°C
• Boiling Point: 562°Cat760mmHg
• Flash Point: 293.7°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 386.27807232
• Heavy Atom Count: 27
• Complexity: 336

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CO)C(=O)O.C1CCC(CC1)NC2CCCCC2
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.C1CCC(CC1)NC2CCCCC2

Technology Process of Boc-Ser-OH.DCHA

There total 3 articles about Boc-Ser-OH.DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-cyclohexyl-cyclohexanamine (101-83-7) + dimethylsulfonium methylsulfate + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → Dicyclohexylammoniumsalz des N-Boc-Serins (10342-06-0)

Guidance literature:

With triethylamine; In water; Ambient temperature;

DOI:10.1246/bcsj.62.3103

Reference yield: 70.0%

N-tert-butoxycarbonyl-L-serine benzyl ester (59524-02-6) + N-cyclohexyl-cyclohexanamine (101-83-7) → Dicyclohexylammoniumsalz des N-Boc-Serins (10342-06-0)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; acetic acid; for 0.5h; Ambient temperature;

DOI:10.1055/s-1980-29275

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Dicyclohexylammoniumsalz des N-Boc-Serins (10342-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Et₃N / acetonitrile / 5 h / 5 °C

2: 74 percent / Et₃N / H₂O / Ambient temperature

With triethylamine; In water; acetonitrile;

DOI:10.1246/bcsj.62.3103

upstream raw materials:

N-tert-butoxycarbonyl-L-serine benzyl ester

N-cyclohexyl-cyclohexanamine

L-proline

di-tert-butyl dicarbonate

Downstream raw materials:

L-N-(tert-butoxycarbonyl)serine phenacyl ester