6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid

Base Information

• Chemical Name: 6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid
• CAS No.: 2638-99-5
• Molecular Formula: C10H9 N O4
• Molecular Weight: 207.18
• DSSTox Substance ID: DTXSID20180979
• Nikkaji Number: J413.170C
• Wikidata: Q83051594
• Mol file: 2638-99-5.mol

Synonyms:5-methoxy-6-hydroxyindole-2-carboxylic acid;6-HMICA;6-hydroxy-5-methoxy-2-indolecarboxylic acid;6-hydroxy-5-methoxy-2-indolylcarboxylic acid;6-hydroxy-5-methoxyindole-2-carboxylic acid;6H5MI2C

Chemical Property of 6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 3.06E-11mmHg at 25°C
• Boiling Point: 510.4°C at 760 mmHg
• Flash Point: 262.5°C
• PSA: 82.55000
• Density: 1.514g/cm³
• LogP: 1.58030
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 207.05315777
• Heavy Atom Count: 15
• Complexity: 258

Purity/Quality:

99% ^*data from raw suppliers

6-hydroxy-5-methoxy-1H-Indole-2-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C=C(N2)C(=O)O)O

Technology Process of 6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid

There total 3 articles about 6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methoxy-6-benzyloxyindole-2-carboxylic acid (2495-92-3) → 5-methoxy-6-hydroxyindole-2-carboxylic acid (2638-99-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 2h; under 760 Torr;

DOI:10.1021/ja0472735

Reference yield:

6-hydroxy-2-ethoxycarbonyl-5-methoxyindole → 5-methoxy-6-hydroxyindole-2-carboxylic acid (2638-99-5)

Guidance literature:

With sulfuric acid; In ethanol; for 2h; Reflux;

Reference yield:

→ 5-methoxy-6-hydroxyindole-2-carboxylic acid (2638-99-5)

Guidance literature:

6-Benzyloxy-5-methoxy-indol-2-carbonsaeure, Pd/C (Raumtemp., Normaldruck), Hydrogenolyse;

upstream raw materials:

5-methoxy-6-benzyloxyindole-2-carboxylic acid

Downstream raw materials:

methyl 3-[(6-hydroxy-5-methoxyindol-2-yl)carbonyl]-(1S)-(chloromethyl)-5-benzyloxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate

methyl 3-[(6-hydroxy-5-methoxyindol-2-yl)carbonyl]-(1R)-(chloromethyl)-5-benzyloxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate

3-[(6-hydroxy-5-methoxyindol-2-yl)carbonyl]-(1R)-(chloromethyl)-5-benzyloxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylic acid

3-[(6-hydroxy-5-methoxyindol-2-yl)carbonyl]-(1S)-(chloromethyl)-5-benzyloxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylic acid