Cyclo(L-leucyl-L-leucyl)

Base Information

Chemical Name:Cyclo(L-leucyl-L-leucyl)
CAS No.:952-45-4
Molecular Formula:C₁₂H₂₂N₂O₂
Molecular Weight:226.319
Hs Code.:
DSSTox Substance ID:DTXSID30241782
Nikkaji Number:J1.331.326A
Wikidata:Q27135732
ChEMBL ID:CHEMBL1957404
Mol file:952-45-4.mol

Synonyms:cyclo-Leu-Leu;cycloleucylleucine

Suppliers and Price of Cyclo(L-leucyl-L-leucyl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cyclo(Leu-Leu)
50mg
$ 1540.00

Biosynth Carbosynth
Cyclo(leu-leu)
50 mg
$ 2400.00

American Custom Chemicals Corporation
3,6-BIS(2-METHYLPROPYL)PIPERAZINE-2,5-DIONE 95.00%
5MG
$ 497.17

Total 11 raw suppliers

Chemical Property of Cyclo(L-leucyl-L-leucyl)

Chemical Property:

Vapor Pressure:4.01E-08mmHg at 25°C
Boiling Point:445.2°Cat760mmHg
Flash Point:177.9°C
PSA：65.18000
Density:0.969g/cm³
LogP:1.61360
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:226.168127949
Heavy Atom Count:16
Complexity:246

Purity/Quality:

99% ^*data from raw suppliers

Cyclo(Leu-Leu) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC1C(=O)NC(C(=O)N1)CC(C)C
Isomeric SMILES:CC(C)C[C@H]1C(=O)N[C@H](C(=O)N1)CC(C)C
Uses A cyclic peptide A cyclic peptide, one of the secondary metabolite of a mangrove endophytic fungus (No. 1947) from the South China Sea.

Technology Process of Cyclo(L-leucyl-L-leucyl)

There total 42 articles about Cyclo(L-leucyl-L-leucyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 952-43-2,952-45-4,16679-66-6,16679-67-7,63729-97-5,1436-27-7
3,6-diisobutyl-2,5-piperazinedione

Guidance literature:: In N,N-dimethyl-formamide; at 200 ℃; for 0.333333h; under 12901.3 Torr; Microwave irradiation;
DOI:10.1039/c1gc15043j

Reference yield: 90.0%

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 952-43-2,952-45-4,1436-27-7,16679-66-6,16679-67-7,63729-97-5
(3S,6S)-3,6-diisobutylpiperazine-2,5-dione

Guidance literature:: N-tert-butoxycarbonyl-L-leucine; With dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;

N-tert-butoxycarbonyl-L-leucine; Further stages;
DOI:10.1016/j.tet.2015.08.051