4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

Base Information

Chemical Name:4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
CAS No.:159182-43-1
Molecular Formula:C₃₀H₄₀N₄O₆S
Molecular Weight:584.737
Hs Code.:
UNII:H3HB4MCV7G
DSSTox Substance ID:DTXSID901104874
Nikkaji Number:J1.995.743H
Wikidata:Q27078423
Pharos Ligand ID:6YCDM3D2J61G
ChEMBL ID:CHEMBL12998
Mol file:159182-43-1.mol

Synonyms:L 755507;L-755,507

Suppliers and Price of 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
L-755,507
10mg
$ 452.00

TRC
L755507
5mg
$ 590.00

Tocris
L-755,507 ≥98%(HPLC)
50
$ 795.00

Tocris
L-755,507 ≥98%(HPLC)
10
$ 189.00

Sigma-Aldrich
L755507 ≥98% (HPLC)
5mg
$ 140.00

Sigma-Aldrich
L755507 ≥98% (HPLC)
25mg
$ 563.00

DC Chemicals
L-755,507 >98%
250 mg
$ 850.00

DC Chemicals
L-755,507 >98%
100 mg
$ 450.00

Crysdot
L-755507 97%
10mg
$ 146.00

ChemScene
L755507 98.33%
5mg
$ 360.00

Total 15 raw suppliers

Chemical Property of 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:8.85±0.10(Predicted)
Flash Point:°C
PSA：157.40000
Density:1.274g/cm³
LogP:6.47540
Storage Temp.:Desiccate at RT
Solubility.:Soluble in DMSO
XLogP3:4.3
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:17
Exact Mass:584.26685618
Heavy Atom Count:41
Complexity:817

Purity/Quality:

99%, ^*data from raw suppliers

L-755,507 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
Isomeric SMILES:CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[C@@H](COC3=CC=C(C=C3)O)O
Uses L755507 is a novel, potent, and selective β3 adrenergic receptor (β3-AR) that can enhance CRISPR genome editing in pluripotent stem cells. It may also serve as a potential therapeutic target for the treatment of type II diabetes and obesity. L755507 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Technology Process of 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

There total 3 articles about 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenoxy]-2-hydroxy-propyl}-(2-{4-[4-(3-hexyl-ureido)-benzenesulfonylamino]-phenyl}-ethyl)-carbamic acid tert-butyl ester

: 159182-43-1
L 755507

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1016/S0960-894X(98)00170-X

Reference yield:

: 173901-02-5
4-[[(hexylamino)carbonyl]-amino]benzenesulfonyl chloride

: 159182-43-1
L 755507

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: HCl / methanol

With pyridine; hydrogenchloride; In methanol;
DOI:10.1016/S0960-894X(98)00170-X

Reference yield:

: 159182-39-5
[2-(4-Amino-phenyl)-ethyl]-{(S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

: 159182-43-1
L 755507

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: HCl / methanol

With pyridine; hydrogenchloride; In methanol;
DOI:10.1016/S0960-894X(98)00170-X