Methionylphenylalanine

Base Information

• Chemical Name: Methionylphenylalanine
• CAS No.: 14492-14-9
• Molecular Formula: C₁₄H₂₀N₂O₃S
• Molecular Weight: 296.39
• Hs Code.: 2930909090
• NSC Number: 322477
• DSSTox Substance ID: DTXSID40932452
• Mol file: 14492-14-9.mol

Synonyms:Met-Phe;methionylphenylalanine

Chemical Property of Methionylphenylalanine

Chemical Property:

• Vapor Pressure: 2.62E-13mmHg at 25°C
• Boiling Point: 558.5°Cat760mmHg
• Flash Point: 291.5°C
• PSA: 117.72000
• Density: 1.233g/cm³
• LogP: 1.97010
• Storage Temp.: -15°C
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 296.11946368
• Heavy Atom Count: 20
• Complexity: 320

Purity/Quality:

99% ^*data from raw suppliers

H-Met-Phe-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CSCCC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)N
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Technology Process of Methionylphenylalanine

There total 2 articles about Methionylphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Met-OMe (10332-17-9,874219-77-9) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → met-Phe (14492-14-9)

Guidance literature:

With aminolysin-A; In water; dimethyl sulfoxide; at 50 ℃; for 6h; pH=8; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0ob00403k

Reference yield:

L-phenylalanine-p-nitroanilide (2360-97-6,14235-17-7,14235-18-8,97471-44-8) → met-Phe (14492-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: S₉-ACAP / water; dimethyl sulfoxide / 0.5 h / 65 °C / pH 6.4 / aq. buffer; Enzymatic reaction

2: aminolysin-A / water; dimethyl sulfoxide / 6 h / 50 °C / pH 8 / aq. phosphate buffer; Enzymatic reaction

With aminolysin-A; S₉-ACAP; In water; dimethyl sulfoxide;

DOI:10.1039/c0ob00403k

Reference yield:

met-Phe (14492-14-9) → N-MOC-Met-Phe-OMe sulfoxide

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / 0 - 20 °C / pH 10.5

2: aq. HCl / 12 h / Heating

3: aq. H₂O₂ / methanol / -20 °C

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; In methanol;

DOI:10.1139/v02-025

upstream raw materials:

Met-OMe

L-phenylalanine

L-phenylalanine-p-nitroanilide

Downstream raw materials:

N-MOC-Met-Phe-OMe