amantadine-N-mustard

Base Information

• Chemical Name: amantadine-N-mustard
• CAS No.: 5592-71-2
• Molecular Formula: C₁₄H₂₃Cl₂N
• Molecular Weight: 276.249
• Mol file: 5592-71-2.mol

Synonyms:1-Adamantanamine,N,N-bis(2-chloroethyl)- (7CI,8CI); 1-[N,N-Bis(b-chloroethyl)amino]adamantane

Chemical Property of amantadine-N-mustard

Chemical Property:

• Vapor Pressure: 0.00081mmHg at 25°C
• Boiling Point: 305.7°Cat760mmHg
• Flash Point: 138.7°C
• PSA: 3.24000
• Density: 1.17g/cm³
• LogP: 3.73480

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of amantadine-N-mustard

There total 3 articles about amantadine-N-mustard which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1--adamantan (3716-67-4) → 1-adamantan (5592-71-2)

Guidance literature:

With thionyl chloride; In tetrahydrofuran;

DOI:10.1021/jm00288a019

Reference yield:

amantadine hydrochloride (665-66-7,13878-11-0) → 1-adamantan (5592-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O

2: SOCl₂ / tetrahydrofuran

With thionyl chloride; In tetrahydrofuran; water;

DOI:10.1021/jm00288a019

Reference yield:

→ 1-adamantan (5592-71-2)

Guidance literature:

1--adamantan*HCl, SOCl2;

DOI:10.1007/BF00760189

upstream raw materials:

1--adamantan

amantadine hydrochloride