2-AMINO-5-BROMO-3-IODOBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-5-BROMO-3-IODOBENZOIC ACID
• CAS No.: 6288-59-1
• Molecular Formula: C7H5BrINO2
• Molecular Weight: 341.931
• Mol file: 6288-59-1.mol

Synonyms:2-amino-5-bromo-3-iodo-benzoic acid;3-azanyl-6-bromanyl-1H-pyrazin-2-one;2-Amino-5-brom-3-jod-benzoesaeure;2-Amino-5-brom-3-hydroxy-pyrazin;

Chemical Property of 2-AMINO-5-BROMO-3-IODOBENZOIC ACID

Chemical Property:

• Vapor Pressure: 7.34E-07mmHg at 25°C
• Boiling Point: 392.4°Cat760mmHg
• Flash Point: 191.1°C
• PSA: 63.32000
• Density: 2.399g/cm³
• LogP: 2.91530

Purity/Quality:

99%min ^*data from raw suppliers

2-Amino-5-bromo-3-iodo-benzoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-3-IODOBENZOIC ACID

There total 1 articles about 2-AMINO-5-BROMO-3-IODOBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-amino-5-bromo-3-iodobenzoic acid (6288-59-1)

Guidance literature:

With Iodine monochloride;

Reference yield:

2-amino-5-bromo-3-iodobenzoic acid (6288-59-1) → C7H7BrINO

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

2-amino-5-bromo-3-iodobenzoic acid (6288-59-1) → (E)-4-((4-amino-6-bromo-8-(4-(2-cyanovinyl)-2,6-dimethylphenyl)quinazolin-2-yl)amino)benzonitrile

Guidance literature:

Multi-step reaction with 5 steps

1: 3 h / 200 °C

2: N,N-dimethyl-formamide; trichlorophosphate / 14 h / 120 °C

3: ammonia / ethanol / 14 h / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate / N,N-dimethyl-formamide; water / 24 h / 20 °C / Inert atmosphere

5: isopropyl alcohol / 0.5 h / 170 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate; ammonia; N,N-dimethyl-formamide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 4: |Suzuki Coupling;

upstream raw materials:

5-Bromo-2-aminobenzoic acid

Refernces

• 1、 -. "QUINAZOLINE DERIVATIVES USED TO TREAT HIV". Paragraph 0309. . Retrieved 2016/07/27.