18-Hydroxyprogesterone

Base Information

Chemical Name:18-Hydroxyprogesterone
CAS No.:596-69-0
Molecular Formula:C21H30 O3
Molecular Weight:330.467
Hs Code.:
European Community (EC) Number:209-889-1
DSSTox Substance ID:DTXSID80975005
Nikkaji Number:J252.485F
Wikidata:Q82959488
Mol file:596-69-0.mol

Synonyms:18-hydroxyprogesterone

Suppliers and Price of 18-Hydroxyprogesterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
18α-Hydroxyprogesterone
25mg
$ 585.00

American Custom Chemicals Corporation
18-HYDROXYPROGESTERONE (20ALPHA AND 20BETA OLS) 18,20-HEMIKETAL 95.00%
5MG
$ 503.02

Total 9 raw suppliers

Chemical Property of 18-Hydroxyprogesterone

Chemical Property:

Vapor Pressure:8.39E-12mmHg at 25°C
Boiling Point:493.4°Cat760mmHg
Flash Point:266.3°C
PSA：54.37000
Density:1.15g/cm³
LogP:3.69590
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:330.21949481
Heavy Atom Count:24
Complexity:606

Purity/Quality:

99% ^*data from raw suppliers

18α-Hydroxyprogesterone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)CO
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)CO
General Description 18-Hydroxyprogesterone is a steroid hormone and a derivative of progesterone, formed through hydroxylation at the 18-position. It serves as an intermediate in the biosynthesis of aldosterone, a critical mineralocorticoid involved in regulating electrolyte and fluid balance. Elevated levels of 18-hydroxyprogesterone are often associated with congenital adrenal hyperplasia (CAH), particularly in cases of 11β-hydroxylase or 17α-hydroxylase deficiencies, where it may accumulate due to impaired enzymatic conversion. Its measurement is clinically useful in diagnosing and monitoring certain adrenal disorders.

Technology Process of 18-Hydroxyprogesterone

There total 8 articles about 18-Hydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56896-04-9
18,20-epoxy-pregna-4,20-dien-3-one

: 596-69-0
18-hydroxypregn-4-ene-3,20-dione

Guidance literature:: With hydrogenchloride;
DOI:10.1021/ja01513a068

Reference yield:

: 102543-82-8
21-(dimethyl-oxy-amino)-18,20β_F-epoxy-pregn-4-en-3-one

: 596-69-0
18-hydroxypregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butylbenzene

2: aqueous HCl

With hydrogenchloride; tert-butylbenzene;
DOI:10.1021/ja01513a068