Chemical Property of Antimycin A3
Chemical Property:
- Vapor Pressure:5.45E-23mmHg at 25°C
- Melting Point:170.5-171.5° (Liu); 174-174.5° (Kinoshita)
- Refractive Index:1.5300 (estimate)
- Boiling Point:745.5°Cat760mmHg
- Flash Point:404.7°C
- PSA：157.33000
- Density:1.25g/cm3
- LogP:3.80000
- Storage Temp.:−20°C
- XLogP3:4.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:10
- Exact Mass:520.24208073
- Heavy Atom Count:37
- Complexity:818
- Purity/Quality:
-
99% *data from raw suppliers
AntimycinA3 ≥98.0% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T
- Statements:
23/24/25
- Safety Statements:
36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
- Isomeric SMILES:CCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
- Recent ClinicalTrials:A Phase I Open Label Study to Assess PK and Safety of Plant Cannabis Extract
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Uses
Antimycin A3 is a homologue of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A4. Antimycin A3 is a more polar analogue of A1 and A2. Like all antimycins, antimycin A3 is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. Lack of availability of the individual antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the antimycin complex.
