2-[(2-nitrophenoxy)methyl]oxirane

Base Information

• Chemical Name: 2-[(2-nitrophenoxy)methyl]oxirane
• CAS No.: 21407-49-8
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Mol file: 21407-49-8.mol

Synonyms:(2-Nitrophenoxymethyl)oxirane;1,2-Epoxy-3-(2-nitrophenoxy)propane;Oxirane,[(2-nitrophenoxy)methyl]- (9CI);Propane, 1,2-epoxy-3-(o-nitrophenoxy)-(6CI,7CI,8CI);1,2-Epoxy-3-(o-nitrophenoxy)propane;2-[(2-Nitrophenoxy)methyl]oxirane;Glycidyl 2-nitrophenyl ether;Glycidylo-nitrophenyl ether;NSC 1734;

Chemical Property of 2-[(2-nitrophenoxy)methyl]oxirane

Chemical Property:

• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 341.4 °C at 760 mmHg
• Flash Point: 170.3 °C
• PSA: 67.58000
• Density: 1.34g/cm³
• LogP: 1.89560

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Nitro-phenoxymethyl)-oxirane 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-nitrophenoxy)methyl]oxirane

There total 8 articles about 2-[(2-nitrophenoxy)methyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-hydroxynitrobenzene (88-75-5,78813-12-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-nitrophenyl glycidyl ether (21407-49-8)

Guidance literature:

With n-Bu₄NOSO₂OCH₂CHOHCH₃; potassium carbonate; at 75 - 80 ℃; for 2.5h;

DOI:10.1080/00397919408011305

Reference yield: 66.0%

glycidol-o-nitrobenzenesulfate (106662-78-6) → 2-nitrophenyl glycidyl ether (21407-49-8)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 60 ℃; for 24h;

DOI:10.1080/00397911.2016.1258579

Reference yield: 41.0%

2-hydroxynitrobenzene (88-75-5,78813-12-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1,3-bis-(2-nitrophenoxy)propan-2-ol (112605-49-9) + 2-nitrophenyl glycidyl ether (21407-49-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 60 ℃;

upstream raw materials:

peracetic acid

2-allyloxy-1-nitrobenzene

1,3-Dichloro-2-propanol

2-hydroxynitrobenzene

Downstream raw materials:

N-[2-hydroxy-3-(2-nitro-phenoxy)-propyl]-succinimide

2-(2-Chloro-phenyl)-N-{2-[2-hydroxy-3-(2-nitro-phenoxy)-propylamino]-propyl}-acetamide

1-(2-nitrophenoxy)-3-β-isobutyramidoethylamino-2-propanol

2-[2-hydroxy-3-(2-nitrophenoxy)propyl]isoindole-1,3-dione