4-(2-fluoroprop-2-en-1-yl)-1,2-dimethoxybenzene

Base Information

• Chemical Name: 4-(2-fluoroprop-2-en-1-yl)-1,2-dimethoxybenzene
• CAS No.: 161436-13-1
• Molecular Formula: C₁₁H₁₃FO₂
• Molecular Weight: 196.221
• Mol file: 161436-13-1.mol

Synonyms:Benzene,4-(2-fluoro-2-propenyl)-1,2-dimethoxy- (9CI)

Chemical Property of 4-(2-fluoroprop-2-en-1-yl)-1,2-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 0.0295mmHg at 25°C
• Boiling Point: 253.2°C at 760 mmHg
• Flash Point: 114.1°C
• Density: 1.048g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-fluoroprop-2-en-1-yl)-1,2-dimethoxybenzene

There total 2 articles about 4-(2-fluoroprop-2-en-1-yl)-1,2-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-Dimethoxy-4-(2-fluoro-3-iodopropyl)benzene → 1,2-Dimethoxy-4-(2-fluoro-2-propenyl)benzene (161436-13-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 6h; Yield given; Heating;

DOI:10.1021/jo00105a019

Reference yield:

1,2-dimethoxy-4-(2-propenyl)benzene (93-15-2) → 1,2-Dimethoxy-4-(2-fluoro-2-propenyl)benzene (161436-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HBF₄*Et₂O, IPy₂BF₄ / CH₂Cl₂ / 1.) -60 deg C, 15 min, 2.) -70 deg C, 1 h

2: DBU / benzene / 6 h / Heating

With tetrafluoroboric acid diethyl ether; Barluenga reagent; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; benzene;

DOI:10.1021/jo00105a019

upstream raw materials:

1,2-dimethoxy-4-(2-propenyl)benzene

Refernces