Penicillamine disulfide

Base Information

• Chemical Name: Penicillamine disulfide
• CAS No.: 312-10-7
• Deprecated CAS: 21174-80-1
• Molecular Formula: C10H20 N2 O4 S2
• Molecular Weight: 296.412
• Hs Code.: 2930909090
• NSC Number: 87505
• UNII: 2218J7AI50
• Nikkaji Number: J3.044.552J
• Wikidata: Q27253594
• Mol file: 312-10-7.mol

Synonyms:penicillamine disulfide;penicillamine disulfide, (D)-isomer

Chemical Property of Penicillamine disulfide

Chemical Property:

• Boiling Point: 467°Cat760mmHg
• Flash Point: 236.2°C
• PSA: 177.24000
• Density: 1.353g/cm³
• LogP: 2.14940
• XLogP3: -5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 296.08644947
• Heavy Atom Count: 18
• Complexity: 302

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(C(=O)O)N)SSC(C)(C)C(C(=O)O)N

Technology Process of Penicillamine disulfide

There total 5 articles about Penicillamine disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

DL-Penicillamin (52-66-4) + benzylarsonic acid → DL-penicillamine disulfide (312-10-7) + C17H27AsN2O4S2

Guidance literature:

In water; for 168h;

Reference yield:

S-nitroso-N-acetylpenicillamine (67809-83-0,73466-15-6) → DL-Penicillamin (52-66-4) + DL-penicillamine disulfide (312-10-7)

Guidance literature:

With ethylenediaminetetraacetic acid; buffer reagents; ascorbic acid; In water; Further Variations:; Reagents; Kinetics;

Reference yield:

DL-Penicillamin (52-66-4) → meso-β,β'-disulfanediyl-di-valine (687973-24-6) + racem.-β,β'-disulfanediyl-di-valine (312-10-7,20902-45-8,21174-80-1,34508-23-1,113626-33-8,115586-46-4)

Guidance literature:

With lithium hydroxide; iron(III) chloride;

upstream raw materials:

DL-Penicillamin

S-nitroso-N-acetylpenicillamine

trans,trans,trans-[PtCl₂(OH)2(c-C₆H₁₁NH₂)(NH₃)]

Downstream raw materials:

α,α'-bis-(toluene-4-sulfonylamino)-β,β'-disulfanediyl-di-isovaleric acid

Refernces

• 1、 Lemma,Shi,Elding. "Kinetics and mechanism for reduction of the anticancer prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM335) by thiols.". . p. 1728 - 1734. Retrieved 2008/10/08.