3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone

Base Information

Chemical Name:3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone
CAS No.:79106-47-1
Molecular Formula:C₂₁H₂₃Cl₂N₃O₂
Molecular Weight:420.339
Hs Code.:
DSSTox Substance ID:DTXSID301000268

Synonyms:79106-47-1;1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-(3,4-dihydro-2(1H)-quinazolinon-3-yl)piperidine;3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone;3-{1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-piperidinyl}-3,4-dihydro-2(1H)-quinazolinone;2(1H)-Quinazolinone, 3,4-dihydro-3-(1-(2-(3,4-dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-;C21H23Cl2N3O2;SCHEMBL11105185;DTXSID301000268;LS-140736;3-{1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]piperidin-4-yl}-3,4-dihydroquinazolin-2-ol

Suppliers and Price of 3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone

Chemical Property:

Vapor Pressure:5.8E-17mmHg at 25°C
Boiling Point:634.3°Cat760mmHg
Flash Point:337.4°C
Density:1.349g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:419.1167324
Heavy Atom Count:28
Complexity:544

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1N2CC3=CC=CC=C3NC2=O)CC(C4=CC(=C(C=C4)Cl)Cl)O

Technology Process of 3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone

There total 9 articles about 3-(1-(2-(3,4-Dichlorophenyl)-2-hydroxyethyl)-4-piperidinyl)-3,4-Dihydro-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.6%

: 79098-78-5
1-(3,4-dichlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

: 79106-47-1
1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Guidance literature:: With sodium tetrahydroborate; In methanol; for 5h; Ambient temperature;
DOI:10.1248/cpb.33.1116

Reference yield:

: 1205-72-7
1-benzyl-4-amino-piperidine dihydrochloride

: 79106-47-1
1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1) TEA; 2) NaBH₄ / 1) room temp., 1 h; 2) room temp. 2h

2: 46.4 percent / hydrogen / 10percent Pd-C / H₂O / Ambient temperature

3: 54.5 percent / TEA / acetonitrile / 4 h / Ambient temperature

4: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C

5: 48 percent / TEA / methanol / Ambient temperature

6: 56.6 percent / NaBH₄ / methanol / 5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; TEA; hydrogen; palladium on activated charcoal; In methanol; water; acetonitrile;
DOI:10.1248/cpb.33.1116

Reference yield:

: 79098-88-7
1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine

: 79106-47-1
1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C

2: 48 percent / TEA / methanol / Ambient temperature

3: 56.6 percent / NaBH₄ / methanol / 5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; TEA; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1248/cpb.33.1116